pfdn6.L prefoldin subunit 6 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pfdn6.L
Official Full Name: prefoldin subunit 6 L homeolog
Primary source: Xenbase:XB-GENE-6252463
Locus tag: XELAEV_18039128mg
See related: EnsemblRapid:ENSXLAG00005032338 AllianceGenome:Xenbase:XB-GENE-6252463
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hke2; ke-2; pfd6; pfdn6; h2-ke2; pfdn6a; pfdn6b; pfdn6-a; pfdn6-b
Summary: Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to act upstream of or within chaperone-mediated protein complex assembly and protein folding. Predicted to be located in cytoplasm. Predicted to be part of prefoldin complex. Is expressed in anatomical system; ectoderm; and pharyngeal arch. Orthologous to human PFDN6 (prefoldin subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (63838777..63844996)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (50655542..50661815)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the pfnd6a expression pattern overlaps with that of tcp1alpha indicating a spatio-temporal transcriptional coregulation in the majority of their expression sites suggestive of a possible involvement in the same developmental events.
Title: Comparative expression analysis of pfdn6a and tcp1α during Xenopus development.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chaperone-mediated protein complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of prefoldin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prefoldin subunit 6 L homeolog

Names: prefoldin subunit 6 b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096949.1 → NP_001090418.1 prefoldin subunit 6 L homeolog

See identical proteins and their annotated locations for NP_001090418.1

Status: PROVISIONAL

Source sequence(s)

BC123375

UniProtKB/TrEMBL

A0A974C7A5, Q0IH09

Related

ENSXLAP00005097079.1, ENSXLAT00005098860.1

Conserved Domains (1) summary

cd00632
Location:9 → 113

Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...