spef1.S sperm flagellar 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: spef1.S
Official Full Name: sperm flagellar 1 S homeolog
Primary source: Xenbase:XB-GENE-6252466
Locus tag: XELAEV_18008768mg
See related: EnsemblRapid:ENSXLAG00005000711 AllianceGenome:Xenbase:XB-GENE-6252466
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: CLAMP; spef1; spef1a; spef1.L
Summary: Enables microtubule binding activity. Acts upstream of or within cell migration and regulation of Wnt signaling pathway, planar cell polarity pathway. Located in apical plasma membrane and axoneme. Orthologous to human SPEF1 (sperm flagellar 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1S

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (3599951..3613871, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (3490473..3504982, complement)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLAMP facilitates the establishment of cell polarity and promotes the asymmetric accumulation of microtubules downstream of the establishment of proper planar cell polarity.
Title: CLAMP/Spef1 regulates planar cell polarity signaling and asymmetric microtubule accumulation in the Xenopus ciliated epithelia.
Subcellular localization of CLAMP promotes the establishment of an axis of microtubule stability required for the active migration of cells into the outer epithelium.
Title: Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonemal central apparatus assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium movement	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cytoskeleton organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in axonemal central apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary tip	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sperm flagellar protein 1

Names: calponin-homology and microtubule-associated protein; sperm flagellar 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.