nemp1.S nuclear envelope integral membrane protein 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nemp1.S
Official Full Name: nuclear envelope integral membrane protein 1 S homeolog
Primary source: Xenbase:XB-GENE-6252472
Locus tag: XELAEV_18015910mg
See related: EnsemblRapid:ENSXLAG00005029395 AllianceGenome:Xenbase:XB-GENE-6252472
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nemp1; nemp1a; nemp1b; nemp1.L; tmem194a; tmem194aa; tmem194a-a
Summary: Acts upstream of or within eye development. Located in nuclear inner membrane. Is expressed in anatomical system; ectoderm; and pharyngeal arch. Orthologous to human NEMP1 (nuclear envelope integral membrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (130748072..130765903, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (121743453..121761365, complement)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that Nemp1 is involved in the expression of eye marker genes by functioning at the inner nuclear membrane at least partly through BAF.
Title: Involvement of an inner nuclear membrane protein, Nemp1, in Xenopus neural development through an interaction with the chromatin protein BAF.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within erythrocyte enucleation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within erythrocyte maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte maturation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear envelope integral membrane protein 1a

Names: nuclear envelope integral membrane protein 1 L homeolog; transmembrane protein 194A a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096922.1 → NP_001090391.1 nuclear envelope integral membrane protein 1a precursor

See identical proteins and their annotated locations for NP_001090391.1

Status: PROVISIONAL

Source sequence(s)

BC123326

UniProtKB/Swiss-Prot

B9X187, Q0IH41

UniProtKB/TrEMBL

A0A974DIZ5

Related

ENSXLAP00005088421.1, ENSXLAT00005090083.1

Conserved Domains (1) summary

pfam10225
Location:166 → 388

DUF2215; Uncharacterized conserved protein (DUF2215)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

130748072..130765903 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)