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stk4.L serine/threonine kinase 4 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 779226, updated on 4-Nov-2024

Summary

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Official Symbol
stk4.L
Official Full Name
serine/threonine kinase 4 L homeolog
Primary source
Xenbase:XB-GENE-17342334
Locus tag
XELAEV_18043241mg
See related
EnsemblRapid:ENSXLAG00005027228 AllianceGenome:Xenbase:XB-GENE-17342334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
krs2; mst1; stk4; ysk3
Summary
Predicted to enable ATP binding activity and histone H2AS1 kinase activity. Predicted to act upstream of or within several processes, including protein phosphorylation; protein tetramerization; and regulation of MAPK cascade. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human STK4 (serine/threonine kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See stk4.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (3780426..3796101)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (3754148..3770424)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta L homeolog Neighboring gene poly(A) binding protein, cytoplasmic 1-like L homeolog Neighboring gene potassium voltage-gated channel, modifier subfamily S, member 1 L homeolog Neighboring gene matrilin 4 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC154361

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine kinase 4 L homeolog
NP_001090317.1
XP_018090135.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096848.1 → NP_001090317.1  serine/threonine kinase 4 L homeolog

    See identical proteins and their annotated locations for NP_001090317.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123162
    UniProtKB/TrEMBL
    Q0IHG7
    Conserved Domains (2) summary
    cd06612
    Location:26 → 276
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:30 → 276
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    3780426..3796101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018234646.2 → XP_018090135.1  serine/threonine kinase 4 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8ES34, A0A974BSQ5, A0A974BWZ1
    Related
    ENSXLAP00005081065.1, ENSXLAT00005082676.1
Nucleotide Protein Strain
Heading Accession and Version

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