mapkapk3.S MAPK activated protein kinase 3 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mapkapk3.S
Official Full Name: MAPK activated protein kinase 3 S homeolog
Primary source: Xenbase:XB-GENE-866582
Locus tag: XELAEV_18025792mg
See related: EnsemblRapid:ENSXLAG00005017615 AllianceGenome:Xenbase:XB-GENE-866582
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mapkapk3; mapkapk3.L
Summary: Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within several processes, including intracellular signal transduction; protein phosphorylation; and toll-like receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (106555232..106589502, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (100136536..100171586, complement)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein autophosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cytokine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MAPK activated protein kinase 3 S homeolog

Names: mitogen-activated protein kinase-activated protein kinase 3 L homeolog; mitogen-activated protein kinase-activated protein kinase 3 S homeolog

NP_001090316.1

EC 2.7.11.1

XP_018115270.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096847.1 → NP_001090316.1 MAPK activated protein kinase 3 S homeolog

See identical proteins and their annotated locations for NP_001090316.1

Status: PROVISIONAL

Source sequence(s)

BC123161

UniProtKB/TrEMBL

A0A974D2N4, Q0IHG8

Conserved Domains (1) summary

cd14172
Location:31 → 297

STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

106555232..106589502 complement

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GenBank, FASTA, Sequence Viewer (Graphics)