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akr1c2.S aldo-keto reductase family 1, member C2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 779224, updated on 4-Nov-2024

Summary

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Official Symbol
akr1c2.S
Official Full Name
aldo-keto reductase family 1, member C2 S homeolog
Primary source
Xenbase:XB-GENE-5844251
Locus tag
XELAEV_18019826mg
See related
EnsemblRapid:ENSXLAG00005000623 AllianceGenome:Xenbase:XB-GENE-5844251
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dd2; babp; ddh2; hbab; hakrd; mcdr2; srxy8; akr1c2; akr1c2-a; akr1c2-b; akr1c2.L
Summary
Predicted to enable aldose reductase (NADPH) activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity. Predicted to act upstream of or within steroid metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C2 (aldo-keto reductase family 1 member C2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See akr1c2.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (4503899..4511868)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (4513906..4521480)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein DDB_G0287113 Neighboring gene aldo-keto reductase family 1, member C8 S homeolog Neighboring gene aldo-keto reductase family 1, member C4 S homeolog Neighboring gene aldo-keto reductase family 1, member D1 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC154357

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables ketosteroid monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables steroid dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1, member C2 S homeolog
Names
3-alpha-hydroxysteroid dehydrogenase
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
aldo-keto reductase family 1, member C2 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096846.1 → NP_001090315.1  aldo-keto reductase family 1, member C2 S homeolog

    See identical proteins and their annotated locations for NP_001090315.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123159
    UniProtKB/TrEMBL
    A0A974HQE7, Q05AX7
    Related
    ENSXLAP00005001770.1, ENSXLAT00005001811.1
    Conserved Domains (2) summary
    COG0656
    Location:8 → 307
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:7 → 300
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    4503899..4511868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018254477.2 → XP_018109966.1  aldo-keto reductase family 1, member C2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UN36, A0A974HQE7
    Related
    ENSXLAP00005001769.1, ENSXLAT00005001810.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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