mnx1.L motor neuron and pancreas homeobox 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mnx1.L
Official Full Name: motor neuron and pancreas homeobox 1 L homeolog
Primary source: Xenbase:XB-GENE-1113190
Locus tag: XELAEV_18030682mg
See related: EnsemblRapid:ENSXLAG00005023066 AllianceGenome:Xenbase:XB-GENE-1113190
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hb9; mnx1; hlxb9; scra1; hoxhb9
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to act upstream of or within endocrine pancreas development; neuron differentiation; and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in ectoderm; endoderm; nervous system; and visual system. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6L

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (16040480..16051817, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (13588697..13600404, complement)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocrine pancreas development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord motor neuron cell fate specification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: motor neuron and pancreas homeobox 1 L homeolog

Names: homeo box HB9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001096823.1 → NP_001090292.1 motor neuron and pancreas homeobox 1 L homeolog

See identical proteins and their annotated locations for NP_001090292.1

Status: PROVISIONAL

Source sequence(s)

BC108589

UniProtKB/TrEMBL

A0A974CLP3, Q32NJ8, Q3KQ52

Related

ENSXLAP00005067964.1, ENSXLAT00005069498.1

Conserved Domains (2) summary

pfam00046
Location:172 → 225

Homeobox; Homeobox domain

cl02310
Location:1 → 127

Glyco_hydro_81; Glycosyl hydrolase family 81

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

16040480..16051817 complement

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GenBank, FASTA, Sequence Viewer (Graphics)