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scn2b sodium channel, voltage-gated, type II, beta [ Danio rerio (zebrafish) ]

Gene ID: 777666, updated on 18-Sep-2024

Summary

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Official Symbol
scn2bprovided by ZNC
Official Full Name
sodium channel, voltage-gated, type II, betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070920-1
See related
Ensembl:ENSDARG00000101713 AllianceGenome:ZFIN:ZDB-GENE-070920-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable sodium channel regulator activity. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in plasma membrane. Is expressed in brain; eye; gill; heart; and liver. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human SCN2B (sodium voltage-gated channel beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See scn2b in Genome Data Viewer
Location:
chromosome: 15
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (12516188..12545683, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (12589970..12614266, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 4a Neighboring gene sodium channel, voltage-gated, type IV, beta a Neighboring gene uncharacterized LOC137487724 Neighboring gene uncharacterized LOC110437893 Neighboring gene uncharacterized LOC101884926 Neighboring gene uncharacterized LOC101887068 Neighboring gene PWWP domain-containing DNA repair factor 3B-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and molecular characterization of the interleukin-10 receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius auratus L.). Grayfer L, et al. Dev Comp Immunol, 2012 Feb. PMID 21906622
  2. Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates. Chopra SS, et al. BMC Evol Biol, 2007 Jul 10. PMID 17623065, Free PMC Article
  3. Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Tsata V, et al. Front Cell Neurosci, 2019. PMID 31031593, Free PMC Article
  4. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac muscle cell action potential involved in contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane depolarization during cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium channel subunit beta-2
Names
voltage-gated sodium channel beta 2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346412.1 → NP_001333341.1  sodium channel subunit beta-2

    Status: VALIDATED

    Source sequence(s)
    CU019627
    UniProtKB/TrEMBL
    A0A8M1P5J4, Q06W28
    Related
    ENSDARP00000131257.1, ENSDART00000162807.2

RNA

  1. NR_144433.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CU019627

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    12516188..12545683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077629.1: Suppressed sequence

    Description
    NM_001077629.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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