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ZNF223 zinc finger protein 223 [ Homo sapiens (human) ]

Gene ID: 7766, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF223provided by HGNC
Official Full Name
zinc finger protein 223provided by HGNC
Primary source
HGNC:HGNC:13016
See related
Ensembl:ENSG00000178386 AllianceGenome:HGNC:13016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in thyroid (RPKM 1.4), urinary bladder (RPKM 1.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44051631..44067999)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46874542..46890907)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44556189..44572152)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF222 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14750 Neighboring gene zinc finger protein 222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44555855-44556356 Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14752 Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41. Rosati M, et al. Cytogenet Cell Genet, 1999. PMID 10449920
  2. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. Shannon M, et al. Genomics, 1996 Apr 1. PMID 8617494
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  4. The protein interaction landscape of the human CMGC kinase group. Varjosalo M, et al. Cell Rep, 2013 Apr 25. PMID 23602568
  5. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 223
Names
Homo sapiens zinc finger protein 223
KRAB A domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034021.1 RefSeqGene

    Range
    5026..20989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013361.6 → NP_037493.3  zinc finger protein 223

    See identical proteins and their annotated locations for NP_037493.3

    Status: VALIDATED

    Source sequence(s)
    AC092072, AF187989, BC022466, DR761157, HY311227
    Consensus CDS
    CCDS12635.1
    UniProtKB/Swiss-Prot
    Q15736, Q8TBJ3, Q9HCA9, Q9UK11
    Related
    ENSP00000401947.1, ENST00000434772.8
    Conserved Domains (6) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:139 → 380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:346 → 366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:294 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:218 → 243
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44051631..44067999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027258.2 → XP_016882747.1  zinc finger protein 223 isoform X1

    UniProtKB/Swiss-Prot
    Q15736, Q8TBJ3, Q9HCA9, Q9UK11
    Conserved Domains (6) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:139 → 380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:346 → 366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:294 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:218 → 243
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017027259.2 → XP_016882748.1  zinc finger protein 223 isoform X1

    UniProtKB/Swiss-Prot
    Q15736, Q8TBJ3, Q9HCA9, Q9UK11
    Conserved Domains (6) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:139 → 380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:346 → 366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:294 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:218 → 243
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017027260.3 → XP_016882749.1  zinc finger protein 223 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46874542..46890907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322025.1 → XP_054178000.1  zinc finger protein 223 isoform X1

  2. XM_054322024.1 → XP_054177999.1  zinc finger protein 223 isoform X1

  3. XM_054322026.1 → XP_054178001.1  zinc finger protein 223 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UK11.2 GenPept UniProtKB/Swiss-Prot:Q9UK11

Gene LinkOut

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