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ZFAND5 zinc finger AN1-type containing 5 [ Homo sapiens (human) ]

Gene ID: 7763, updated on 5-Mar-2024

Summary

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Official Symbol
ZFAND5provided by HGNC
Official Full Name
zinc finger AN1-type containing 5provided by HGNC
Primary source
HGNC:HGNC:13008
See related
Ensembl:ENSG00000107372 MIM:604761; AllianceGenome:HGNC:13008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZA20D2; ZNF216; ZFAND5A
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to act upstream of or within several processes, including face development; fibroblast migration; and platelet-derived growth factor receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 113.8), adrenal (RPKM 84.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ZFAND5 in Genome Data Viewer
Location:
9q21.13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (72351413..72365208, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (84502257..84516065, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (74966329..74980124, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 285 Neighboring gene long intergenic non-protein coding RNA 1504 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:74930554-74931102 Neighboring gene hESC enhancers GRCh37_chr9:74979127-74979830 and GRCh37_chr9:74979831-74980535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28458 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:75069728-75070499 Neighboring gene ribosomal protein S12 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28459 Neighboring gene Sharpr-MPRA regulatory region 9116 Neighboring gene uncharacterized LOC105376080

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity. Mincione G, et al. Oncotarget, 2016 Nov 15. PMID 27732953, Free PMC Article
  2. A RANKL-inducible gene Znf216 in osteoclast differentiation. Hishiya A, et al. J Recept Signal Transduct Res, 2005. PMID 16194934
  3. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Scott DA, et al. Gene, 1998 Jul 30. PMID 9758550
  4. The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions. He G, et al. J Biol Chem, 2012 Jul 20. PMID 22665488, Free PMC Article
  5. Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex. Garner TP, et al. Biochemistry, 2011 Oct 25. PMID 21923101

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results indicate that ZNF216 overexpression sensitizes to apoptosis the NIH3T3/EGFR/ZNF216 cells thus antagonizing the effect of activated EGFR-mediated survival in control cells that do not overexpress the ZNF216.
    Title: Identification of the zinc finger 216 (ZNF216) in human carcinoma cells: a potential regulator of EGFR activity.
  2. Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin for mRNA binding.
    Title: The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions.
  3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  5. redundant and distinct roles in regulating NFkappaB activation and apoptosis
    Title: ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.
  6. ZNF216 is a potent inhibitory factor for osteoclast differentiation and the mechanism is unlikely due to direct attenuation of the NF-kappa B pathway
    Title: A RANKL-inducible gene Znf216 in osteoclast differentiation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in face development IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in respiratory system process IEA
Inferred from Electronic Annotation
more info
  
involved_in skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth muscle tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in vasculature development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AN1-type zinc finger protein 5
Names
zinc finger A20 domain-containing protein 2
zinc finger protein 216
zinc finger, A20 domain containing 2
zinc finger, AN1-type domain 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102420.3 → NP_001095890.1  AN1-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_001095890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript. All six variants encode the same protein.
    Source sequence(s)
    AL135924
    Consensus CDS
    CCDS6642.1
    UniProtKB/Swiss-Prot
    A8K484, O76080
    Related
    ENSP00000366161.5, ENST00000376962.10
    Conserved Domains (2) summary
    smart00154
    Location:154 → 191
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  2. NM_001102421.3 → NP_001095891.1  AN1-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_001095891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
    Source sequence(s)
    AL135924
    Consensus CDS
    CCDS6642.1
    UniProtKB/Swiss-Prot
    A8K484, O76080
    Related
    ENSP00000366159.4, ENST00000376960.8
    Conserved Domains (2) summary
    smart00154
    Location:154 → 191
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  3. NM_001278243.2 → NP_001265172.1  AN1-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_001265172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
    Source sequence(s)
    AL135924
    Consensus CDS
    CCDS6642.1
    UniProtKB/Swiss-Prot
    A8K484, O76080
    Related
    ENSP00000350586.2, ENST00000343431.6
    Conserved Domains (2) summary
    smart00154
    Location:154 → 191
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  4. NM_001278244.1 → NP_001265173.1  AN1-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_001265173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
    Source sequence(s)
    AL135924, BC073131, BX489434, DA290666
    Consensus CDS
    CCDS6642.1
    UniProtKB/Swiss-Prot
    A8K484, O76080
    Related
    ENSP00000237937.3, ENST00000237937.7
    Conserved Domains (2) summary
    smart00154
    Location:154 → 191
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  5. NM_001278245.2 → NP_001265174.1  AN1-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_001265174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (f) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
    Source sequence(s)
    AL135924
    Consensus CDS
    CCDS6642.1
    UniProtKB/Swiss-Prot
    A8K484, O76080
    Conserved Domains (2) summary
    smart00154
    Location:154 → 191
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  6. NM_006007.4 → NP_005998.1  AN1-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_005998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) differs in the 5' UTR compared to variant a. All six variants encode the same protein.
    Source sequence(s)
    AL135924
    Consensus CDS
    CCDS6642.1
    UniProtKB/Swiss-Prot
    A8K484, O76080
    Conserved Domains (2) summary
    smart00154
    Location:154 → 191
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    72351413..72365208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423853.1 → XP_047279809.1  AN1-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K484, O76080

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    84502257..84516065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363768.1 → XP_054219743.1  AN1-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A8K484, O76080
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76080.1 GenPept UniProtKB/Swiss-Prot:O76080

Gene LinkOut

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