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Apex2 apurinic/apyrimidinic endonuclease 2 [ Mus musculus (house mouse) ]

Gene ID: 77622, updated on 28-Oct-2024

Summary

Official Symbol
Apex2provided by MGI
Official Full Name
apurinic/apyrimidinic endonuclease 2provided by MGI
Primary source
MGI:MGI:1924872
See related
Ensembl:ENSMUSG00000025269 AllianceGenome:MGI:1924872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ape2; C430040P13Rik
Summary
Predicted to enable DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA 3'-5' DNA exonuclease activity; and phosphoric diester hydrolase activity. Predicted to be involved in base-excision repair. Located in mitochondrial inner membrane and nucleus. Orthologous to human APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in liver E14.5 (RPKM 5.0), liver E14 (RPKM 4.2) and 28 other tissues See more
Orthologs
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Genomic context

See Apex2 in Genome Data Viewer
Location:
X F3; X 68.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149286625..149371175, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150426974..150588206, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene methylphosphate capping enzyme pseudogene Neighboring gene VCP nuclear cofactor family member 2 Neighboring gene STARR-positive B cell enhancer mm9_chrX:146893310-146893611 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48069 Neighboring gene STARR-seq mESC enhancer starr_48070 Neighboring gene microRNA 3620 Neighboring gene Alas2R1 erythroid cis-regulatory module Neighboring gene aminolevulinic acid synthase 2, erythroid Neighboring gene Alas2R3 erythroid cis-regulatory module Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Neighboring gene trophinin Neighboring gene voltage-dependent anion channel 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA 3'-5' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-(apurinic or apyrimidinic site) endonuclease 2
Names
AP endonuclease 2
APEX nuclease 2
DNA-(apurinic or apyrimidinic site) lyase 2
NP_084219.1
XP_006529054.1
XP_011246181.1
XP_030107378.1
XP_036018008.1
XP_036018009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029943.3NP_084219.1  DNA-(apurinic or apyrimidinic site) endonuclease 2

    See identical proteins and their annotated locations for NP_084219.1

    Status: VALIDATED

    Source sequence(s)
    AL672150
    Consensus CDS
    CCDS30463.1
    UniProtKB/Swiss-Prot
    Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12
    UniProtKB/TrEMBL
    A2AFM3
    Related
    ENSMUSP00000026303.10, ENSMUST00000026303.16
    Conserved Domains (2) summary
    cd09088
    Location:3310
    Ape2-like_AP-endo; Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
    pfam06839
    Location:463512
    zf-GRF; GRF zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    149286625..149371175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251518.2XP_030107378.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X2

    UniProtKB/TrEMBL
    F7CPY7
    Related
    ENSMUSP00000108345.2, ENSMUST00000112725.8
    Conserved Domains (1) summary
    cl00490
    Location:3222
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. XM_036162115.1XP_036018008.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X4

    UniProtKB/TrEMBL
    F7CPY7
    Conserved Domains (1) summary
    cl00490
    Location:3223
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. XM_036162116.1XP_036018009.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X5

    UniProtKB/TrEMBL
    A2AFM5
    Related
    ENSMUSP00000108339.2, ENSMUST00000112719.2
    Conserved Domains (1) summary
    cl00490
    Location:3213
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  4. XM_011247879.4XP_011246181.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X3

    UniProtKB/TrEMBL
    F7CPY7
    Conserved Domains (1) summary
    cl00490
    Location:3223
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  5. XM_006528991.4XP_006529054.1  DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X1

    UniProtKB/Swiss-Prot
    Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12
    Conserved Domains (2) summary
    cd09088
    Location:3320
    Ape2-like_AP-endo; Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
    pfam06839
    Location:473522
    zf-GRF; GRF zinc finger

RNA

  1. XR_878269.4 RNA Sequence

  2. XR_878270.4 RNA Sequence