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CACNA1D calcium voltage-gated channel subunit alpha1 D [ Homo sapiens (human) ]

Gene ID: 776, updated on 28-Oct-2024

Summary

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Official Symbol
CACNA1Dprovided by HGNC
Official Full Name
calcium voltage-gated channel subunit alpha1 Dprovided by HGNC
Primary source
HGNC:HGNC:1391
See related
Ensembl:ENSG00000157388 MIM:114206; AllianceGenome:HGNC:1391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2
Summary
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Broad expression in adrenal (RPKM 4.1), lung (RPKM 2.3) and 16 other tissues See more
Orthologs
mouse all
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Genomic context

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See CACNA1D in Genome Data Viewer
Location:
3p21.1
Exon count:
55
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (53494611..53813733)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (53527880..53846976)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53528638..53847760)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA26 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:53507244-53507747 Neighboring gene Sharpr-MPRA regulatory region 2578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53528087-53528586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53528917-53529702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53529703-53530487 Neighboring gene ribosomal protein S25 pseudogene 4 Neighboring gene NANOG hESC enhancer GRCh37_chr3:53545870-53546371 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:53559857-53561056 Neighboring gene NANOG hESC enhancer GRCh37_chr3:53565752-53566253 Neighboring gene NANOG hESC enhancer GRCh37_chr3:53579614-53580115 Neighboring gene uncharacterized LOC124906242 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:53750142-53751341 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53752305-53752885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53752886-53753466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53765682-53766222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53766223-53766761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53787515-53788014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53798133-53798649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53802933-53803434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:53838519-53839320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53840931-53841432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53841433-53841932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53857324-53857923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:53878721-53879561 Neighboring gene Sharpr-MPRA regulatory region 239 Neighboring gene choline dehydrogenase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14469 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:53925074-53925974 Neighboring gene interleukin 17 receptor B Neighboring gene actin related protein 8 Neighboring gene selenoprotein K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ca(V)1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy. Schwenzer N, et al. Commun Biol, 2024 May 23. PMID 38783117, Free PMC Article
  2. Gating defects of disease-causing de novo mutations in Ca(v)1.3 Ca(2+) channels. Pinggera A, et al. Channels (Austin), 2018. PMID 30465465, Free PMC Article
  3. Characterization of an L-type calcium channel expressed by human retinal Müller (glial) cells. Puro DG, et al. Brain Res Mol Brain Res, 1996 Apr. PMID 8738134
  4. Role of a conserved glutamine in the function of voltage-gated Ca(2+) channels revealed by a mutation in human CACNA1D. Garza-Lopez E, et al. J Biol Chem, 2018 Sep 14. PMID 30054272, Free PMC Article
  5. alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. Koschak A, et al. J Biol Chem, 2001 Jun 22. PMID 11285265

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pathogenicity of de novo CACNA1D Ca[2+] channel variants predicted from sequence co-variation.
    Title: Pathogenicity of de novo CACNA1D Ca(2+) channel variants predicted from sequence co-variation.
  2. Association between CACNA1D polymorphisms and hypospadias in a southern Chinese population.
    Title: Association between CACNA1D polymorphisms and hypospadias in a southern Chinese population.
  3. CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy.
    Title: Ca(V)1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy.
  4. CACNA1D Gene Polymorphisms Associate With Increased Blood Pressure and Salt Sensitivity of Blood Pressure in White Individuals.
    Title: CACNA1D Gene Polymorphisms Associate With Increased Blood Pressure and Salt Sensitivity of Blood Pressure in White Individuals.
  5. The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice.
    Title: The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice.
  6. CACNA1D-Related Channelopathies: From Hypertension to Autism.
    Title: CACNA1D-Related Channelopathies: From Hypertension to Autism.
  7. CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation.
    Title: CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation.
  8. The ubiquitin E3 ligase Parkin regulates neuronal CaV1.3 channel functional expression.
    Title: The ubiquitin E3 ligase Parkin regulates neuronal Ca(V)1.3 channel functional expression.
  9. Whole Exome Sequencing Identifies a Heterozygous Variant in the Cav1.3 Gene CACNA1D Associated with Familial Sinus Node Dysfunction and Focal Idiopathic Epilepsy.
    Title: Whole Exome Sequencing Identifies a Heterozygous Variant in the Cav1.3 Gene CACNA1D Associated with Familial Sinus Node Dysfunction and Focal Idiopathic Epilepsy.
  10. Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults.
    Title: Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults.
Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Aldosterone-producing adenoma with seizures and neurological abnormalities
MedGen: C3809609 OMIM: 615474 GeneReviews: Not available
Compare labs
Sinoatrial node dysfunction and deafness
MedGen: C3554018 OMIM: 614896 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
EBI GWAS Catalog
Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.
EBI GWAS Catalog
Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
EBI GWAS Catalog
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
EBI GWAS Catalog
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-actinin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ankyrin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to high voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables voltage-gated calcium channel activity involved SA node cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables voltage-gated calcium channel activity involved in cardiac muscle cell action potential IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in calcium ion import IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cardiac muscle cell action potential involved in contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane depolarization during SA node cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane depolarization during cardiac muscle cell action potential IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of atrial cardiac muscle cell membrane repolarization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of potassium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of L-type voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent L-type calcium channel subunit alpha-1D
Names
calcium channel, L type, alpha-1 polypeptide
calcium channel, neuroendocrine/brain-type, alpha 1 subunit
calcium channel, voltage-dependent, L type, alpha 1D subunit
voltage-gated calcium channel alpha 1 subunit
voltage-gated calcium channel alpha subunit Cav1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032999.1 RefSeqGene

    Range
    4563..323685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000720.4 → NP_000711.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform a

    See identical proteins and their annotated locations for NP_000711.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB209171, AC005905, AC012467, AC132810, AW008794, M76558, M83566
    Consensus CDS
    CCDS2872.1
    UniProtKB/TrEMBL
    H0Y879
    Related
    ENSP00000288139.3, ENST00000288139.11
    Conserved Domains (4) summary
    pfam00520
    Location:1242 → 1495
    Ion_trans; Ion transport protein
    pfam08763
    Location:1568 → 1639
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1663 → 2178
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1503 → 1566
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. NM_001128839.3 → NP_001122311.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform c

    See identical proteins and their annotated locations for NP_001122311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC005905, AC012467, AC132810, AW008794, EU363339, M76558, M83566
    Consensus CDS
    CCDS46849.1
    UniProtKB/TrEMBL
    A0A7G9IPG1
    Related
    ENSP00000409174.2, ENST00000422281.7
    Conserved Domains (4) summary
    pfam00520
    Location:125 → 417
    Ion_trans; Ion transport protein
    pfam08763
    Location:1532 → 1606
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1627 → 2134
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1469 → 1522
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. NM_001128840.3 → NP_001122312.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform b

    See identical proteins and their annotated locations for NP_001122312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AB209171, AC005905, AC012467, AC132810, AW008794, M76558, M83566
    Consensus CDS
    CCDS46848.1
    UniProtKB/Swiss-Prot
    B0FYA3, Q01668, Q13916, Q13931, Q71UT1, Q9UDC3
    UniProtKB/TrEMBL
    A0A7G9IPG1
    Related
    ENSP00000288133.5, ENST00000350061.11
    Conserved Domains (4) summary
    pfam00520
    Location:1222 → 1475
    Ion_trans; Ion transport protein
    pfam08763
    Location:1548 → 1619
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1643 → 2158
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1483 → 1546
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    53494611..53813733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265448.4 → XP_005265505.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X14

    UniProtKB/TrEMBL
    A0A1B0GUN6, A0A7G9IPG1
    Related
    ENSP00000490183.1, ENST00000636570.1
    Conserved Domains (4) summary
    pfam00520
    Location:1222 → 1460
    Ion_trans; Ion transport protein
    pfam08763
    Location:1533 → 1604
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1628 → 2143
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1468 → 1531
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_047448874.1 → XP_047304830.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X18

    Related
    ENSP00000490039.1, ENST00000636938.1

  3. XM_011534094.3 → XP_011532396.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

    UniProtKB/TrEMBL
    H0Y879
    Conserved Domains (4) summary
    pfam00520
    Location:180 → 454
    Ion_trans; Ion transport protein
    pfam08763
    Location:1633 → 1704
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1728 → 2243
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1568 → 1631
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_017007144.2 → XP_016862633.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

    UniProtKB/TrEMBL
    H0Y879
    Related
    ENSP00000418014.2, ENST00000481478.2

  5. XM_017007141.2 → XP_016862630.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

    UniProtKB/TrEMBL
    A0A7G9IPG1

  6. XM_017007137.2 → XP_016862626.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

    UniProtKB/TrEMBL
    H0Y879

  7. XM_017007139.2 → XP_016862628.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

    UniProtKB/TrEMBL
    H0Y879

  8. XM_047448871.1 → XP_047304827.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

  9. XM_017007142.2 → XP_016862631.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

    UniProtKB/TrEMBL
    H0Y879

  10. XM_017007145.2 → XP_016862634.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

    UniProtKB/TrEMBL
    H0Y879

  11. XM_047448872.1 → XP_047304828.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X12

  12. XM_017007143.2 → XP_016862632.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

    UniProtKB/TrEMBL
    H0Y879

  13. XM_017007138.2 → XP_016862627.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

    UniProtKB/TrEMBL
    H0Y879

  14. XM_017007140.2 → XP_016862629.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

    UniProtKB/TrEMBL
    A0A7G9IPG1

  15. XM_011534100.3 → XP_011532402.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X19

    UniProtKB/TrEMBL
    A0A7G9IPG1
    Conserved Domains (4) summary
    pfam00520
    Location:180 → 454
    Ion_trans; Ion transport protein
    pfam08763
    Location:1598 → 1669
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1693 → 2208
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1533 → 1596
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  16. XM_011534096.3 → XP_011532398.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X13

    UniProtKB/TrEMBL
    A0A7G9IPG1
    Related
    ENSP00000489769.1, ENST00000637424.1
    Conserved Domains (4) summary
    pfam00520
    Location:1259 → 1497
    Ion_trans; Ion transport protein
    pfam08763
    Location:1570 → 1641
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1665 → 2180
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1505 → 1568
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  17. XM_047448873.1 → XP_047304829.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X17

    Related
    ENSP00000490889.2, ENST00000636627.2

  18. XM_011534097.3 → XP_011532399.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X15

    See identical proteins and their annotated locations for XP_011532399.1

    UniProtKB/TrEMBL
    H0Y879
    Conserved Domains (4) summary
    pfam00520
    Location:14 → 275
    Ion_trans; Ion transport protein
    pfam08763
    Location:1454 → 1525
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1549 → 2064
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1389 → 1452
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  19. XM_011534099.3 → XP_011532401.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X16

    UniProtKB/TrEMBL
    Q59GD8
    Conserved Domains (4) summary
    pfam00520
    Location:975 → 1256
    Ion_trans; Ion transport protein
    pfam08763
    Location:1329 → 1400
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1424 → 1939
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1264 → 1327
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    53527880..53846976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347781.1 → XP_054203756.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X14

    UniProtKB/TrEMBL
    A0A1B0GUN6

  2. XM_054347785.1 → XP_054203760.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X18

  3. XM_054347769.1 → XP_054203744.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

  4. XM_054347775.1 → XP_054203750.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

  5. XM_054347773.1 → XP_054203748.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

  6. XM_054347768.1 → XP_054203743.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

  7. XM_054347771.1 → XP_054203746.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

  8. XM_054347774.1 → XP_054203749.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

  9. XM_054347777.1 → XP_054203752.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

  10. XM_054347778.1 → XP_054203753.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

  11. XM_054347779.1 → XP_054203754.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X12

  12. XM_054347776.1 → XP_054203751.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

  13. XM_054347770.1 → XP_054203745.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

  14. XM_054347772.1 → XP_054203747.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

  15. XM_054347786.1 → XP_054203761.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X19

  16. XM_054347780.1 → XP_054203755.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X13

  17. XM_054347784.1 → XP_054203759.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X17

  18. XM_054347782.1 → XP_054203757.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X15

  19. XM_054347783.1 → XP_054203758.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X16

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01668.2 GenPept UniProtKB/Swiss-Prot:Q01668

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