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ZNF205 zinc finger protein 205 [ Homo sapiens (human) ]

Gene ID: 7755, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF205provided by HGNC
Official Full Name
zinc finger protein 205provided by HGNC
Primary source
HGNC:HGNC:12996
See related
Ensembl:ENSG00000122386 MIM:603436; AllianceGenome:HGNC:12996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RhitH; Zfp13; ZNF210
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of hydrogen peroxide biosynthetic process; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 3.3), ovary (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3112586..3120517)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3138563..3147008)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3162587..3170518)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3139191-3139721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3140253-3140782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3142715-3143302 Neighboring gene zinc finger and SCAN domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7114 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3151352-3152052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3154929-3155612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3155613-3156296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7118 Neighboring gene uncharacterized LOC124903629 Neighboring gene ZNF205 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3163522-3164110 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3174278-3174547 Neighboring gene ZNF213 antisense RNA 1 (head to head) Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:3177693-3178243 Neighboring gene Sharpr-MPRA regulatory region 2057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3188465-3188965 Neighboring gene zinc finger protein 213

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of two Krüppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. Deng Z, et al. Genomics, 1998 Oct 1. PMID 9787081
  2. A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism. Iida R, et al. Mol Cell Biol, 2010 May. PMID 20231359, Free PMC Article
  3. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. Iida R, et al. Free Radic Biol Med, 2012 Apr 15. PMID 22306510
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Yeung ML, et al. J Biol Chem, 2009 Jul 17. PMID 19460752, Free PMC Article
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF205 positively regulates RLR antiviral signaling by targeting RIG-I.
    Title: ZNF205 positively regulates RLR antiviral signaling by targeting RIG-I.
  2. that knockdown of RhitH or overexpression of M-LPH reduces the generation of intracellular H(2)O(2) and loss of mitochondrial membrane potential caused by an inhibitor of the respiratory chain, antimycin A
    Title: Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 205 (ZNF205) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcriptional repressor RHIT
Names
repressor of heat-inducible transcription
transcriptional repressor RhitH
zinc finger protein 210

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042428.2 → NP_001035893.1  transcriptional repressor RHIT

    See identical proteins and their annotated locations for NP_001035893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' non-coding region and has a shorter 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC108134, BM924902, CB152017
    Consensus CDS
    CCDS10494.2
    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
    Related
    ENSP00000219091.4, ENST00000219091.9
    Conserved Domains (6) summary
    smart00349
    Location:124 → 168
    KRAB; krueppel associated box
    COG5048
    Location:306 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422 → 442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476 → 498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:124 → 161
    KRAB; KRAB box
    pfam13465
    Location:434 → 459
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001278158.2 → NP_001265087.1  transcriptional repressor RHIT

    See identical proteins and their annotated locations for NP_001265087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate donor splice site in the 5' non-coding region and has a longer 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB672633, AF060865, BC002810
    Consensus CDS
    CCDS10494.2
    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
    Related
    ENSP00000480401.1, ENST00000620094.4
    Conserved Domains (6) summary
    smart00349
    Location:124 → 168
    KRAB; krueppel associated box
    COG5048
    Location:306 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422 → 442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476 → 498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:124 → 161
    KRAB; KRAB box
    pfam13465
    Location:434 → 459
    zf-H2C2_2; Zinc-finger double domain

  3. NM_003456.3 → NP_003447.2  transcriptional repressor RHIT

    See identical proteins and their annotated locations for NP_003447.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AF060865, BI826058, CB152017
    Consensus CDS
    CCDS10494.2
    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
    Related
    ENSP00000371627.3, ENST00000382192.7
    Conserved Domains (6) summary
    smart00349
    Location:124 → 168
    KRAB; krueppel associated box
    COG5048
    Location:306 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422 → 442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476 → 498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:124 → 161
    KRAB; KRAB box
    pfam13465
    Location:434 → 459
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3112586..3120517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255558.3 → XP_005255615.1  transcriptional repressor RHIT isoform X1

    See identical proteins and their annotated locations for XP_005255615.1

    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95
    Conserved Domains (6) summary
    smart00349
    Location:124 → 168
    KRAB; krueppel associated box
    COG5048
    Location:306 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422 → 442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:476 → 498
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:124 → 161
    KRAB; KRAB box
    pfam13465
    Location:434 → 459
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047434601.1 → XP_047290557.1  transcriptional repressor RHIT isoform X1

    UniProtKB/Swiss-Prot
    A8MZK0, D3DUB4, I0J0A3, O95201, Q9BU95

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3138563..3147008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313870.1 → XP_054169845.1  transcriptional repressor RHIT isoform X1

  2. XM_054313869.1 → XP_054169844.1  transcriptional repressor RHIT isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95201.2 GenPept UniProtKB/Swiss-Prot:O95201

Gene LinkOut

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