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Mtus2 microtubule associated tumor suppressor candidate 2 [ Mus musculus (house mouse) ]

Gene ID: 77521, updated on 2-Nov-2024

Summary

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Official Symbol
Mtus2provided by MGI
Official Full Name
microtubule associated tumor suppressor candidate 2provided by MGI
Primary source
MGI:MGI:1915388
See related
Ensembl:ENSMUSG00000029651 AllianceGenome:MGI:1915388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cazip; Gm763; mKIAA0774; 5730592G18Rik; A730013O20Rik; C130038G02Rik
Summary
Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be located in intercellular bridge and microtubule cytoskeleton. Predicted to be active in nucleus. Predicted to colocalize with centrosome and cytoplasmic microtubule. Is expressed in several structures, including central nervous system; eye; heart; peripheral nervous system; and respiratory system. Orthologous to human MTUS2 (microtubule associated scaffold protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 15.8), cerebellum adult (RPKM 6.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Mtus2 in Genome Data Viewer
Location:
5 G3; 5 87.82 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147894085..148252875)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147957275..148316065)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E534 Neighboring gene solute carrier family 46, member 3 Neighboring gene STARR-seq mESC enhancer starr_14888 Neighboring gene predicted gene, 46943 Neighboring gene STARR-seq mESC enhancer starr_14889 Neighboring gene STARR-seq mESC enhancer starr_14890 Neighboring gene STARR-seq mESC enhancer starr_14891 Neighboring gene STARR-seq mESC enhancer starr_14892 Neighboring gene STARR-seq mESC enhancer starr_14893 Neighboring gene STARR-seq mESC enhancer starr_14894 Neighboring gene predicted gene, 46928 Neighboring gene STARR-seq mESC enhancer starr_14896 Neighboring gene fused in sarcoma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E675 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 Neighboring gene STARR-seq mESC enhancer starr_14901 Neighboring gene STARR-positive B cell enhancer mm9_chr5:149263482-149263782 Neighboring gene STARR-seq mESC enhancer starr_14907 Neighboring gene ubiquitin-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CAZIP, a novel protein expressed in the developing heart and nervous system. Du Puy L, et al. Dev Dyn, 2009 Nov. PMID 19806667
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microtubule-associated tumor suppressor candidate 2 homolog
Names
cardiac zipper protein
microtubule plus-end tracking protein TIP150
tracking protein of 150 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359503.2 → NP_001346432.1  microtubule-associated tumor suppressor candidate 2 homolog isoform a

    Status: VALIDATED

    Source sequence(s)
    AC109498, AC117725, AC133954, AC158301
    Consensus CDS
    CCDS19881.1
    UniProtKB/Swiss-Prot
    B9EKJ2, Q3UHD3, Q7TPP7, Q8CHD2, Q9CY74
    Conserved Domains (2) summary
    PHA03247
    Location:516 → 974
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:1024 → 1313
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

  2. NM_001359505.2 → NP_001346434.1  microtubule-associated tumor suppressor candidate 2 homolog isoform b

    Status: VALIDATED

    Source sequence(s)
    AC109498, AC158301
    UniProtKB/TrEMBL
    D3YZ69
    Related
    ENSMUSP00000106144.3, ENSMUST00000110515.9
    Conserved Domains (1) summary
    cl25732
    Location:25 → 318
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_001359511.2 → NP_001346440.1  microtubule-associated tumor suppressor candidate 2 homolog isoform c

    Status: VALIDATED

    Source sequence(s)
    AC109498, AC158301
    UniProtKB/TrEMBL
    D3YY58, Q8C1S9
    Related
    ENSMUSP00000071775.6, ENSMUST00000071878.12

  4. NM_001416280.1 → NP_001403209.1  microtubule-associated tumor suppressor candidate 2 homolog isoform d

    Status: VALIDATED

    Source sequence(s)
    AC109498, AC158301
    Related
    ENSMUSP00000106143.2, ENSMUST00000110514.8

  5. NM_029920.8 → NP_084196.4  microtubule-associated tumor suppressor candidate 2 homolog isoform a

    See identical proteins and their annotated locations for NP_084196.4

    Status: VALIDATED

    Source sequence(s)
    AC109498, AC117725, AC133954, AC158301
    Consensus CDS
    CCDS19881.1
    UniProtKB/Swiss-Prot
    B9EKJ2, Q3UHD3, Q7TPP7, Q8CHD2, Q9CY74
    Related
    ENSMUSP00000082694.5, ENSMUST00000085558.11
    Conserved Domains (2) summary
    PHA03247
    Location:516 → 974
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:1024 → 1313
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147894085..148252875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241018.3 → XP_011239320.1  microtubule-associated tumor suppressor candidate 2 homolog isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:516 → 974
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:1024 → 1280
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

  2. XM_006504891.5 → XP_006504954.1  microtubule-associated tumor suppressor candidate 2 homolog isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:33 → 204
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:304 → 540
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHD3.1 GenPept UniProtKB/Swiss-Prot:Q3UHD3

Gene LinkOut

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