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ZNF200 zinc finger protein 200 [ Homo sapiens (human) ]

Gene ID: 7752, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF200provided by HGNC
Official Full Name
zinc finger protein 200provided by HGNC
Primary source
HGNC:HGNC:12993
See related
Ensembl:ENSG00000010539 MIM:603231; AllianceGenome:HGNC:12993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable metal ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 8.8), appendix (RPKM 2.8) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3222325..3235158, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3249433..3263296, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3272325..3285158, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily F member 1 Neighboring gene tRNA-Lys (anticodon CTT) 14-1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3261768-3261996 Neighboring gene olfactory receptor family 1 subfamily F member 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10315 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:3293322-3294521 Neighboring gene MEFV innate immunity regulator, pyrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10318 Neighboring gene long intergenic non-protein coding RNA 921

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a. Nishida M, et al. Genes Cells, 2007 Jul. PMID 17584299
  2. Identification of two Krüppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. Deng Z, et al. Genomics, 1998 Oct 1. PMID 9787081
  3. A candidate gene for familial Mediterranean fever. French FMF Consortium. Nat Genet, 1997 Sep. PMID 9288094
  4. A transcriptional Map of the FMF region. Bernot A, et al. Genomics, 1998 Jun 1. PMID 9653642
  5. Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. Adams MD, et al. Nat Genet, 1993 Aug. PMID 8401585

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF200 is a novel binding partner of G9a.
    Title: Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45293

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 200

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145446.2 → NP_001138918.1  zinc finger protein 200 isoform 3

    See identical proteins and their annotated locations for NP_001138918.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at the ultimate coding exon compared to transcript variant 1. This results in an isoform (3) missing 1 aa compared to isoform 1. Variants 4,5 and 6 encode the same isoform.
    Source sequence(s)
    AA338573, BC054005, DB031650, Y14443
    Consensus CDS
    CCDS45395.1
    UniProtKB/Swiss-Prot
    P98182
    Related
    ENSP00000380080.4, ENST00000396871.8
    Conserved Domains (4) summary
    COG5048
    Location:253 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265 → 290
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001145447.2 → NP_001138919.1  zinc finger protein 200 isoform 3

    See identical proteins and their annotated locations for NP_001138919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame acceptor splice site at the ultimate coding exon compared to transcript variant 1. This results in an isoform (3) missing 1 aa compared to isoform 1. Variants 4,5 and 6 encode the same isoform.
    Source sequence(s)
    AA338573, AK056010, BC032575
    Consensus CDS
    CCDS45395.1
    UniProtKB/Swiss-Prot
    P98182
    UniProtKB/TrEMBL
    B3KP91
    Related
    ENSP00000380079.4, ENST00000396870.8
    Conserved Domains (4) summary
    COG5048
    Location:253 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265 → 290
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001145448.2 → NP_001138920.1  zinc finger protein 200 isoform 3

    See identical proteins and their annotated locations for NP_001138920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at the ultimate coding exon compared to transcript variant 1. This results in an isoform (3) missing 1 aa compared to isoform 1. Variants 4,5 and 6 encode the same isoform.
    Source sequence(s)
    AA338573, AK315036, DA757518, Y14443
    Consensus CDS
    CCDS45395.1
    UniProtKB/Swiss-Prot
    P98182
    Related
    ENSP00000458508.1, ENST00000575948.1
    Conserved Domains (4) summary
    COG5048
    Location:253 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265 → 290
    zf-H2C2_2; Zinc-finger double domain

  4. NM_003454.4 → NP_003445.2  zinc finger protein 200 isoform 1

    See identical proteins and their annotated locations for NP_003445.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA338573, AK056010, BC032575
    Consensus CDS
    CCDS10497.1
    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1
    Related
    ENSP00000395723.3, ENST00000431561.7
    Conserved Domains (3) summary
    COG5048
    Location:254 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:266 → 291
    zf-H2C2_2; Zinc-finger double domain

  5. NM_198087.3 → NP_932353.1  zinc finger protein 200 isoform 2

    See identical proteins and their annotated locations for NP_932353.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at the penultimate coding exon compared to transcript variant 1. This results in an isoform (2) missing 1 aa compared to isoform 1.
    Source sequence(s)
    AA338573, DB031650, Y14443
    Consensus CDS
    CCDS42112.1
    UniProtKB/Swiss-Prot
    P98182
    Related
    ENSP00000380077.3, ENST00000396868.7
    Conserved Domains (4) summary
    COG5048
    Location:253 → 394
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:265 → 290
    zf-H2C2_2; Zinc-finger double domain

  6. NM_198088.3 → NP_932354.1  zinc finger protein 200 isoform 1

    See identical proteins and their annotated locations for NP_932354.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to transcript variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA338573, AF060866, DA757518, Y14443
    Consensus CDS
    CCDS10497.1
    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1
    Related
    ENSP00000405786.2, ENST00000414144.7
    Conserved Domains (3) summary
    COG5048
    Location:254 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:266 → 291
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3222325..3235158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720941.3 → XP_006721004.1  zinc finger protein 200 isoform X1

    See identical proteins and their annotated locations for XP_006721004.1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1
    Conserved Domains (3) summary
    COG5048
    Location:254 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:266 → 291
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047434596.1 → XP_047290552.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  3. XM_047434599.1 → XP_047290555.1  zinc finger protein 200 isoform X2

  4. XM_047434597.1 → XP_047290553.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  5. XM_047434600.1 → XP_047290556.1  zinc finger protein 200 isoform X2

  6. XM_047434598.1 → XP_047290554.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

RNA

  1. XR_007064908.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3249433..3263296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313857.1 → XP_054169832.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  2. XM_054313867.1 → XP_054169842.1  zinc finger protein 200 isoform X2

  3. XM_054313854.1 → XP_054169829.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  4. XM_054313861.1 → XP_054169836.1  zinc finger protein 200 isoform X2

  5. XM_054313866.1 → XP_054169841.1  zinc finger protein 200 isoform X2

  6. XM_054313868.1 → XP_054169843.1  zinc finger protein 200 isoform X2

  7. XM_054313863.1 → XP_054169838.1  zinc finger protein 200 isoform X2

  8. XM_054313862.1 → XP_054169837.1  zinc finger protein 200 isoform X2

  9. XM_054313856.1 → XP_054169831.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  10. XM_054313852.1 → XP_054169827.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  11. XM_054313855.1 → XP_054169830.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  12. XM_054313860.1 → XP_054169835.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  13. XM_054313864.1 → XP_054169839.1  zinc finger protein 200 isoform X2

  14. XM_054313865.1 → XP_054169840.1  zinc finger protein 200 isoform X2

  15. XM_054313858.1 → XP_054169833.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  16. XM_054313859.1 → XP_054169834.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

  17. XM_054313853.1 → XP_054169828.1  zinc finger protein 200 isoform X1

    UniProtKB/Swiss-Prot
    D3DUB7, D3DUB8, O15361, P98182, Q5XKM5, Q7Z5V1

RNA

  1. XR_008484733.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98182.2 GenPept UniProtKB/Swiss-Prot:P98182

Gene LinkOut

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