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POLY polyprotein [ Zika virus ]

Gene ID: 7751225, updated on 31-Jan-2024

Summary

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Gene symbol
POLY
Gene description
polyprotein
Locus tag
ZIKV_gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Zika virus (strain: MR 766, nat-host: sentinel monkey)
Lineage
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus zikaense
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Genomic context

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Sequence:
NC_012532.1 (107..10366)

NC_012532.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_012532.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Zika virus envelope protein glycan loop regulates virion antigenicity. Goo L, et al. Virology, 2018 Feb. PMID 29304471
  2. MD simulations reveal alternate conformations of the oxyanion hole in the Zika virus NS2B/NS3 protease. Ren J, et al. Proteins, 2020 Feb. PMID 31461176
  3. Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase. Xu S, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31361901, Free PMC Article
  4. Cis autocatalytic cleavage of glycine-linked Zika virus NS2B-NS3 protease constructs. von Hammerstein F, et al. FEBS Lett, 2019 Aug. PMID 31240714
  5. Genetic and biochemical characterizations of Zika virus NS2A protein. Zhang X, et al. Emerg Microbes Infect, 2019. PMID 30958095, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection.
    Title: Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection.
  2. Investigating the conformational dynamics of Zika virus NS4B protein.
    Title: Investigating the conformational dynamics of Zika virus NS4B protein.
  3. Multiple Salivary Proteins from Aedes aegypti Mosquito Bind to the Zika Virus Envelope Protein.
    Title: Multiple Salivary Proteins from Aedes aegypti Mosquito Bind to the Zika Virus Envelope Protein.
  4. Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
    Title: Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
  5. Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
    Title: Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
  6. Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids.
    Title: Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids.
  7. NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling.
    Title: NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling.
  8. Doxycycline Interferes with Zika Virus Serine Protease and Inhibits Virus Replication in Human Skin Fibroblasts.
    Title: Doxycycline Interferes with Zika Virus Serine Protease and Inhibits Virus Replication in Human Skin Fibroblasts.
  9. Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses.
    Title: Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses.
  10. Nuclear localization of Zika virus NS5 contributes to suppression of type I interferon production and response.
    Title: Nuclear localization of Zika virus NS5 contributes to suppression of type I interferon production and response.
Submit: New GeneRIF Correction See all GeneRIFs (57)

General protein information

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Preferred Names
polyprotein
Names
capsid protein C
membrane glycoprotein precursor prM
envelope protein E
nonstructural protein NS1
nonstructural protein NS2A
nonstructural protein NS2B
nonstructural protein NS3
nonstructural protein NS4A
nonstructural protein NS4B
RNA-dependent RNA polymerase NS5
anchored capsid protein ancC
protein pr
membrane glycoprotein M
protein 2K

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012532.1 Reference assembly

    Range
    107..10366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_002790881.1 polyprotein [Zika virus]

    See identical proteins and their annotated locations for YP_002790881.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q32ZE1
    UniProtKB/TrEMBL
    A0A142IX71, A0A1B1UX06
    Conserved Domains (16) summary
    cd12149
    Location:597 → 689
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:694 → 790
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00948
    Location:793 → 1144
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam01002
    Location:1373 → 1498
    Flavi_NS2B; Flavivirus non-structural protein NS2B
    pfam01005
    Location:1154 → 1303
    Flavi_NS2A; Flavivirus non-structural protein NS2A
    pfam01349
    Location:2266 → 2508
    Flavi_NS4B; Flavivirus non-structural protein NS4B
    pfam01350
    Location:2121 → 2265
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam00949
    Location:1515 → 1665
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    cd17038
    Location:216 → 290
    Flavi_M; Flavivirus envelope glycoprotein M
    cd18806
    Location:1831 → 1973
    SF2_C_viral; C-terminal helicase domain of viral helicase
    pfam00869
    Location:292 → 588
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00972
    Location:2768 → 3412
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01003
    Location:12 → 122
    Flavi_capsid; Flavivirus capsid protein C
    pfam01570
    Location:127 → 203
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam07652
    Location:1682 → 1829
    Flavi_DEAD; Flavivirus DEAD domain
    pfam01728
    Location:2571 → 2742
    FtsJ; FtsJ-like methyltransferase

  2. YP_009227196.1 capsid protein C

    Conserved Domains (1) summary
    pfam01003
    Location:12 → 102
    Flavi_capsid; Flavivirus capsid protein C

  3. YP_009227197.1 membrane glycoprotein precursor prM

    Conserved Domains (2) summary
    pfam01004
    Location:95 → 168
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:6 → 92
    Flavi_propep; Flavivirus polyprotein propeptide

  4. YP_009227198.1 envelope protein E

    Conserved Domains (3) summary
    cd12149
    Location:307 → 399
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:404 → 500
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00869
    Location:2 → 298
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains

  5. YP_009227199.1 nonstructural protein NS1

    UniProtKB/TrEMBL
    A0A1D8MBG0
    Conserved Domains (1) summary
    pfam00948
    Location:3 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1

  6. YP_009227200.1 nonstructural protein NS2A

    Conserved Domains (1) summary
    pfam01005
    Location:12 → 161
    Flavi_NS2A; Flavivirus non-structural protein NS2A

  7. YP_009227201.1 nonstructural protein NS2B

    Conserved Domains (1) summary
    pfam01002
    Location:5 → 130
    Flavi_NS2B; Flavivirus non-structural protein NS2B

  8. YP_009227202.1 nonstructural protein NS3

    Conserved Domains (4) summary
    smart00487
    Location:181 → 326
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:357 → 473
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00949
    Location:19 → 167
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam07652
    Location:186 → 331
    Flavi_DEAD; Flavivirus DEAD domain

  9. YP_009227203.1 nonstructural protein NS4A

    Conserved Domains (1) summary
    pfam01350
    Location:6 → 127
    Flavi_NS4A; Flavivirus non-structural protein NS4A

  10. YP_009227204.1 nonstructural protein NS4B

    Conserved Domains (1) summary
    pfam01349
    Location:1 → 243
    Flavi_NS4B; Flavivirus non-structural protein NS4B

  11. YP_009227205.1 RNA-dependent RNA polymerase NS5

    Conserved Domains (2) summary
    pfam00972
    Location:254 → 892
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01728
    Location:55 → 226
    FtsJ; FtsJ-like methyltransferase

  12. YP_009227206.1 anchored capsid protein ancC

    Conserved Domains (1) summary
    pfam01003
    Location:12 → 122
    Flavi_capsid; Flavivirus capsid protein C

  13. YP_009227207.1 protein pr

    Conserved Domains (1) summary
    pfam01570
    Location:6 → 92
    Flavi_propep; Flavivirus polyprotein propeptide

  14. YP_009227208.1 membrane glycoprotein M

    UniProtKB/TrEMBL
    A0A1S7IVW1
    Conserved Domains (1) summary
    pfam01004
    Location:2 → 75
    Flavi_M; Flavivirus envelope glycoprotein M

  15. YP_009227209.1 protein 2K

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32ZE1.1

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