U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZSCAN26 zinc finger and SCAN domain containing 26 [ Homo sapiens (human) ]

Gene ID: 7741, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZSCAN26provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 26provided by HGNC
Primary source
HGNC:HGNC:12978
See related
Ensembl:ENSG00000197062 MIM:616474; AllianceGenome:HGNC:12978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREZBP; ZNF187; SRE-ZBP
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 7.8) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6p22.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28267143..28278204)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28138885..28149946)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28234921..28245981)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17043 Neighboring gene NFKB activating protein like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:28234963-28235527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17044 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28249721-28249897 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:28251848-28252055 Neighboring gene piggyBac transposable element derived 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28278749-28279250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:28279251-28279750 Neighboring gene SMIM15 pseudogene 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element. Attar RM, et al. Mol Cell Biol, 1992 May. PMID 1569959, Free PMC Article
  2. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Kim YC, et al. Proc Natl Acad Sci U S A, 2009 May 19. PMID 19416867, Free PMC Article
  3. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  5. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC2815

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
zinc finger and SCAN domain-containing protein 26
Names
zinc finger protein 187

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001023560.4 → NP_001018854.2  zinc finger and SCAN domain-containing protein 26 isoform a

    See identical proteins and their annotated locations for NP_001018854.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK095948, AL526328, BC013951
    UniProtKB/TrEMBL
    A0A024RCN4
    Related
    ENSP00000481707.1, ENST00000421553.7
    Conserved Domains (6) summary
    smart00431
    Location:52 → 158
    SCAN; leucine rich region
    COG5048
    Location:290 → 469
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285 → 305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:283 → 305
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:47 → 135
    SCAN; SCAN domain
    pfam13465
    Location:297 → 322
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001111039.3 → NP_001104509.1  zinc finger and SCAN domain-containing protein 26 isoform b

    See identical proteins and their annotated locations for NP_001104509.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AK095948, AK301081, BC013951, DA884554
    Consensus CDS
    CCDS78119.1
    UniProtKB/Swiss-Prot
    Q16670, Q5JPG4, Q7Z3Q6, Q96A17
    Related
    ENSP00000485228.1, ENST00000623276.3
    Conserved Domains (6) summary
    smart00431
    Location:52 → 157
    SCAN; leucine rich region
    COG5048
    Location:289 → 468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284 → 304
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:47 → 135
    SCAN; SCAN domain
    pfam13465
    Location:296 → 321
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001287421.2 → NP_001274350.1  zinc finger and SCAN domain-containing protein 26 isoform c

    See identical proteins and their annotated locations for NP_001274350.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant a. Variants c and d encode the same isoform (c), which is shorter than isoform a.
    Source sequence(s)
    AK301081, AL021997, AL832741, DA341149
    Consensus CDS
    CCDS75414.1
    UniProtKB/TrEMBL
    A0A087X2F1
    Related
    ENSP00000479314.1, ENST00000614088.1
    Conserved Domains (3) summary
    COG5048
    Location:174 → 334
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:150 → 170
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:162 → 187
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001287422.2 → NP_001274351.1  zinc finger and SCAN domain-containing protein 26 isoform d

    See identical proteins and their annotated locations for NP_001274351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) lacks two exons in the 5' coding region and initiates translation at a downstream start codon, compared to variant a. It encodes isoform d, which is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK095948, AL832741, DA528922
    Consensus CDS
    CCDS75415.1
    UniProtKB/TrEMBL
    B4DMT1
    Related
    ENSP00000478769.1, ENST00000611552.2
    Conserved Domains (3) summary
    COG5048
    Location:100 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:76 → 96
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:88 → 113
    zf-H2C2_2; Zinc-finger double domain

  5. NM_152736.6 → NP_689949.3  zinc finger and SCAN domain-containing protein 26 isoform c

    See identical proteins and their annotated locations for NP_689949.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) uses an alternate in-frame splice site in the 5' coding region, compared to variant a. Variants c and d encode the same isoform (c), which is shorter than isoform a.
    Source sequence(s)
    BC013951, DB262147
    Consensus CDS
    CCDS75414.1
    UniProtKB/TrEMBL
    A0A087X2F1
    Related
    ENSP00000484931.1, ENST00000316606.10
    Conserved Domains (3) summary
    COG5048
    Location:174 → 334
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:150 → 170
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:162 → 187
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    28267143..28278204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419314.1 → XP_047275270.1  zinc finger and SCAN domain-containing protein 26 isoform X5

  2. XM_011514862.3 → XP_011513164.1  zinc finger and SCAN domain-containing protein 26 isoform X1

    See identical proteins and their annotated locations for XP_011513164.1

    UniProtKB/TrEMBL
    A0A024RCN4
    Related
    ENSP00000484018.1, ENST00000619937.4
    Conserved Domains (6) summary
    smart00431
    Location:52 → 158
    SCAN; leucine rich region
    COG5048
    Location:290 → 469
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285 → 305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:283 → 305
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:47 → 135
    SCAN; SCAN domain
    pfam13465
    Location:297 → 322
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017011264.2 → XP_016866753.1  zinc finger and SCAN domain-containing protein 26 isoform X2

    UniProtKB/Swiss-Prot
    Q16670, Q5JPG4, Q7Z3Q6, Q96A17
    Conserved Domains (6) summary
    smart00431
    Location:52 → 157
    SCAN; leucine rich region
    COG5048
    Location:289 → 468
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284 → 304
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282 → 304
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:47 → 135
    SCAN; SCAN domain
    pfam13465
    Location:296 → 321
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011514864.2 → XP_011513166.1  zinc finger and SCAN domain-containing protein 26 isoform X3

    See identical proteins and their annotated locations for XP_011513166.1

    Conserved Domains (3) summary
    COG5048
    Location:261 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:23 → 129
    SCAN; SCAN oligomerization domain

  5. XM_047419312.1 → XP_047275268.1  zinc finger and SCAN domain-containing protein 26 isoform X4

  6. XM_047419313.1 → XP_047275269.1  zinc finger and SCAN domain-containing protein 26 isoform X5

  7. XM_024446538.2 → XP_024302306.1  zinc finger and SCAN domain-containing protein 26 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:261 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02605
    Location:23 → 129
    SCAN; SCAN oligomerization domain

  8. XM_047419311.1 → XP_047275267.1  zinc finger and SCAN domain-containing protein 26 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    28138885..28149946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356349.1 → XP_054212324.1  zinc finger and SCAN domain-containing protein 26 isoform X5

  2. XM_054356342.1 → XP_054212317.1  zinc finger and SCAN domain-containing protein 26 isoform X1

    UniProtKB/TrEMBL
    A0A024RCN4

  3. XM_054356343.1 → XP_054212318.1  zinc finger and SCAN domain-containing protein 26 isoform X2

    UniProtKB/Swiss-Prot
    Q16670, Q5JPG4, Q7Z3Q6, Q96A17

  4. XM_054356345.1 → XP_054212320.1  zinc finger and SCAN domain-containing protein 26 isoform X3

  5. XM_054356347.1 → XP_054212322.1  zinc finger and SCAN domain-containing protein 26 isoform X4

  6. XM_054356348.1 → XP_054212323.1  zinc finger and SCAN domain-containing protein 26 isoform X5

  7. XM_054356344.1 → XP_054212319.1  zinc finger and SCAN domain-containing protein 26 isoform X3

  8. XM_054356346.1 → XP_054212321.1  zinc finger and SCAN domain-containing protein 26 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007151.1: Suppressed sequence

    Description
    NM_007151.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate when translated from the upstream AUG.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16670.2 GenPept UniProtKB/Swiss-Prot:Q16670

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous