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ZNF174 zinc finger protein 174 [ Homo sapiens (human) ]

Gene ID: 7727, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF174provided by HGNC
Official Full Name
zinc finger protein 174provided by HGNC
Primary source
HGNC:HGNC:12963
See related
Ensembl:ENSG00000103343 MIM:603900; AllianceGenome:HGNC:12963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN8
Summary
This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in ovary (RPKM 4.6), testis (RPKM 4.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3401215..3409364)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3428486..3436629)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3451215..3459364)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-RNR2 like 4 (pseudogene) Neighboring gene zinc finger and SCAN domain containing 32 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3450765-3451264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7133 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3470303-3470585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3481451-3481952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7134 Neighboring gene zinc finger protein 597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10322 Neighboring gene N-alpha-acetyltransferase 60, NatF catalytic subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7135 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_43328 and experimental_43330 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43334 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43335 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3517275-3517812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3519547-3520264 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43345 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43346 Neighboring gene microRNA 6126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The SCAN domain of ZNF174 is a dimer. Stone JR, et al. J Biol Chem, 2002 Feb 15. PMID 11741982, Free PMC Article
  2. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. Ivanov D, et al. Mol Cell, 2005 Jan 7. PMID 15629724
  3. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. Williams AJ, et al. J Biol Chem, 1995 Sep 22. PMID 7673192
  4. Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies. Noll L, et al. Leuk Res, 2008 Oct. PMID 18472161
  5. The zinc finger-associated SCAN box is a conserved oligomerization domain. Williams AJ, et al. Mol Cell Biol, 1999 Dec. PMID 10567577, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: NAA60

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 174
Names
AW-1
zinc finger and SCAN domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053015.1 RefSeqGene

    Range
    5026..13175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032292.3 → NP_001027463.1  zinc finger protein 174 isoform b

    See identical proteins and their annotated locations for NP_001027463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (b) with a different C-terminus compared to isoform a.
    Source sequence(s)
    AC025283, BC001161, BI918471, DA962432
    Consensus CDS
    CCDS32380.1
    UniProtKB/TrEMBL
    Q8IZN5
    Related
    ENSP00000339781.5, ENST00000344823.9
    Conserved Domains (1) summary
    smart00431
    Location:42 → 152
    SCAN; leucine rich region

  2. NM_001347868.2 → NP_001334797.1  zinc finger protein 174 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment of the 5' UTR, compared to transcript variant 1, but encodes the same isoform (a).
    Source sequence(s)
    AC025283, BM969505
    Consensus CDS
    CCDS10504.1
    UniProtKB/Swiss-Prot
    Q15697, Q53Y68, Q9BQ34
    Related
    ENSP00000460397.1, ENST00000571936.5

  3. NM_001347869.2 → NP_001334798.1  zinc finger protein 174 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (c) with a different C-terminus compared to isoform a.
    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS86501.1
    UniProtKB/TrEMBL
    I3L2H2, Q8IZN5
    Related
    ENSP00000459681.1, ENST00000572544.1

  4. NM_001347870.2 → NP_001334799.1  zinc finger protein 174 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks a segment of the 5' UTR and contains an alternative 3' terminal exon, compared to transcript variant 1, resulting in a shorter isoform (c) with a different C-terminus compared to isoform a.
    Source sequence(s)
    AC025283
    Consensus CDS
    CCDS86501.1
    UniProtKB/TrEMBL
    I3L2H2, Q8IZN5

  5. NM_003450.3 → NP_003441.1  zinc finger protein 174 isoform a

    See identical proteins and their annotated locations for NP_003441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC025283, BI918471, BM969505, DA962432, U31248
    Consensus CDS
    CCDS10504.1
    UniProtKB/Swiss-Prot
    Q15697, Q53Y68, Q9BQ34
    Related
    ENSP00000268655.4, ENST00000268655.5
    Conserved Domains (6) summary
    smart00431
    Location:42 → 152
    SCAN; leucine rich region
    COG5048
    Location:352 → 407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:326 → 348
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 130
    SCAN; SCAN domain
    pfam13465
    Location:369 → 393
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3401215..3409364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3428486..3436629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15697.1 GenPept UniProtKB/Swiss-Prot:Q15697

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