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Ticrr TOPBP1-interacting checkpoint and replication regulator [ Mus musculus (house mouse) ]

Gene ID: 77011, updated on 18-Sep-2024

Summary

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Official Symbol
Ticrrprovided by MGI
Official Full Name
TOPBP1-interacting checkpoint and replication regulatorprovided by MGI
Primary source
MGI:MGI:1924261
See related
Ensembl:ENSMUSG00000046591 AllianceGenome:MGI:1924261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrrk1; 5730590G19Rik
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in DNA replication; mitotic G2/M transition checkpoint; and regulation of DNA-dependent DNA replication initiation. Predicted to act upstream of or within DNA repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain ventricular layer and inferior colliculus. Orthologous to human TICRR (TOPBP1 interacting checkpoint and replication regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.1), thymus adult (RPKM 2.9) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Ticrr in Genome Data Viewer
Location:
7 D2; 7 45.09 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79309944..79347896)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79660196..79698148)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Rhesus blood group-associated C glycoprotein Neighboring gene cullin 4B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10444 Neighboring gene STARR-seq mESC enhancer starr_19286 Neighboring gene STARR-positive B cell enhancer ABC_E551 Neighboring gene uncharacterized LOC118567517 Neighboring gene kinesin family member 7 Neighboring gene STARR-positive B cell enhancer mm9_chr7:86873152-86873453 Neighboring gene perilipin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities. Pons S, et al. J Mol Cell Cardiol, 2013 Jan. PMID 23201226
  2. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Sansam CL, et al. Genes Dev, 2010 Jan 15. PMID 20080954, Free PMC Article
  3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated DNA replication initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
treslin
Names
leucine-rich repeat kinase 1
topBP1-interacting, replication-stimulating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029835.1 → NP_084111.1  treslin

    See identical proteins and their annotated locations for NP_084111.1

    Status: VALIDATED

    Source sequence(s)
    AK033104, AK041726, AK051639, BC028450, BC058634, BY731867, CF730550, CN537331
    Consensus CDS
    CCDS21384.1
    UniProtKB/Swiss-Prot
    B2RY55, Q8BQ33, Q8C9N4, Q8CCI2
    Related
    ENSMUSP00000041377.8, ENSMUST00000035977.9
    Conserved Domains (1) summary
    pfam15292
    Location:211 → 1005
    Treslin_N; Treslin N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79309944..79347896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173790.3: Suppressed sequence

    Description
    NM_173790.3: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQ33.2 GenPept UniProtKB/Swiss-Prot:Q8BQ33

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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