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ZNF141 zinc finger protein 141 [ Homo sapiens (human) ]

Gene ID: 7700, updated on 5-May-2024

Summary

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Official Symbol
ZNF141provided by HGNC
Official Full Name
zinc finger protein 141provided by HGNC
Primary source
HGNC:HGNC:12926
See related
Ensembl:ENSG00000131127 MIM:194648; AllianceGenome:HGNC:12926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D4S90; pHZ-44
Summary
The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in adrenal (RPKM 3.7), lymph node (RPKM 3.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
4p16.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (337814..384868)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (331204..378261)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (331603..378657)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 732 Neighboring gene uncharacterized LOC105374336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:330727-331242 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:331348-332308 Neighboring gene microRNA 571 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:388927-389606 Neighboring gene zinc finger protein 519 pseudogene 4 Neighboring gene HERV-FRD provirus ancestral Env polyprotein pseudogene Neighboring gene ATP binding cassette subfamily A member 11, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A. Kalsoom UE, et al. J Med Genet, 2013 Jan. PMID 23160277
  2. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. Tommerup N, et al. Hum Mol Genet, 1993 Oct. PMID 8268908
  3. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Varrault A, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671765, Free PMC Article
  4. Advances in the molecular genetics of non-syndromic polydactyly. Deng H, et al. Expert Rev Mol Med, 2015 Oct 30. PMID 26515020
  5. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. Vissing H, et al. FEBS Lett, 1995 Aug 7. PMID 7649249

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Polydactyly, postaxial, type A6
MedGen: C3808889 OMIM: 615226 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 141
Names
zinc finger protein 141 (clone pHZ-44)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052984.2 RefSeqGene

    Range
    5002..52056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348277.2 → NP_001335206.1  zinc finger protein 141 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC079140, AC092574
    UniProtKB/TrEMBL
    Q4W5N2
    Conserved Domains (3) summary
    COG5048
    Location:42 → 338
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:315 → 395
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:209 → 229
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001348278.2 → NP_001335207.1  zinc finger protein 141 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079140, AC092574
    Consensus CDS
    CCDS87195.1
    UniProtKB/TrEMBL
    D6RIY0
    Related
    ENSP00000425799.1, ENST00000512994.5
    Conserved Domains (1) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box

  3. NM_001348279.2 → NP_001335208.1  zinc finger protein 141 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079140
    Conserved Domains (1) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box

  4. NM_001348280.2 → NP_001335209.1  zinc finger protein 141 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079140
    Conserved Domains (1) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box

  5. NM_003441.4 → NP_003432.1  zinc finger protein 141 isoform 1

    See identical proteins and their annotated locations for NP_003432.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC079140, AC092574
    Consensus CDS
    CCDS33931.1
    UniProtKB/Swiss-Prot
    Q15928, Q6DK07
    Related
    ENSP00000240499.7, ENST00000240499.8
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:118 → 414
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285 → 305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:297 → 322
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    337814..384868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416147.1 → XP_047272103.1  zinc finger protein 141 isoform X3

  2. XM_017008591.3 → XP_016864080.1  zinc finger protein 141 isoform X1

  3. XM_011513562.4 → XP_011511864.1  zinc finger protein 141 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:64 → 103
    KRAB; krueppel associated box
    COG5048
    Location:146 → 442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:313 → 333
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:64 → 103
    KRAB; KRAB box
    pfam13465
    Location:325 → 350
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    331204..378261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350814.1 → XP_054206789.1  zinc finger protein 141 isoform X3

  2. XM_054350812.1 → XP_054206787.1  zinc finger protein 141 isoform X1

  3. XM_054350813.1 → XP_054206788.1  zinc finger protein 141 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15928.1 GenPept UniProtKB/Swiss-Prot:Q15928

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