khdrbs2 KH domain containing, RNA binding, signal transduction associated 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: khdrbs2provided by ZNC
Official Full Name: KH domain containing, RNA binding, signal transduction associated 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-497
See related: Ensembl:ENSDARG00000069469 AllianceGenome:ZFIN:ZDB-GENE-061013-497
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153588
Summary: Predicted to enable mRNA binding activity and poly(A) binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be active in nucleus. Is expressed in central nervous system; eye; and testis. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (23282491..23408527)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (23104647..23278077)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: KH domain-containing, RNA-binding, signal transduction-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077290.1 → NP_001070758.1 KH domain-containing, RNA-binding, signal transduction-associated protein 2

See identical proteins and their annotated locations for NP_001070758.1

Status: PROVISIONAL

Source sequence(s)

BC124701

UniProtKB/Swiss-Prot

Q08BJ2

Related

ENSDARP00000091908.3, ENSDART00000101134.4

Conserved Domains (3) summary

cd02395
Location:61 → 180

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

pfam16274
Location:6 → 57

Qua1; Qua1 domain

pfam16568
Location:281 → 306

Sam68-YY; Tyrosine-rich domain of Sam68