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b4galt1l DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like [ Danio rerio (zebrafish) ]

Gene ID: 768123, updated on 27-Mar-2024

Summary

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Official Symbol
b4galt1lprovided by ZNC
Official Full Name
DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-84
See related
Ensembl:ENSDARG00000104404 AllianceGenome:ZFIN:ZDB-GENE-061013-84
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:154116
Summary
Predicted to enable beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity and cytoskeletal protein binding activity. Predicted to be involved in protein N-linked glycosylation. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See b4galt1l in Genome Data Viewer
Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (52440142..52467513)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (51724448..51751821)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene nitric oxide associated 1 Neighboring gene RE1-silencing transcription factor Neighboring gene exosome component 3 Neighboring gene transcription elongation regulator 1a (CA150)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of natural human β1,4-GalT1 variants and of non-mammalian homologues in plants leads to differences in galactosylation of N-glycans. Hesselink T, et al. Transgenic Res, 2014 Oct. PMID 25082356
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 1
Names
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
NP_001070727.2
XP_005157393.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077259.2 → NP_001070727.2  beta-1,4-galactosyltransferase 1

    See identical proteins and their annotated locations for NP_001070727.2

    Status: VALIDATED

    Source sequence(s)
    AL954718
    UniProtKB/TrEMBL
    A0A8M1NB26, C1KH59
    Related
    ENSDARP00000135827.1, ENSDART00000168437.2
    Conserved Domains (1) summary
    cd00899
    Location:128 → 346
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    52440142..52467513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157336.4 → XP_005157393.1  beta-1,4-galactosyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B441
    Conserved Domains (1) summary
    cd00899
    Location:3 → 178
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Nucleotide Protein Strain
Heading Accession and Version

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