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Bri3bp Bri3 binding protein [ Mus musculus (house mouse) ]

Gene ID: 76809, updated on 2-Nov-2024

Summary

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Official Symbol
Bri3bpprovided by MGI
Official Full Name
Bri3 binding proteinprovided by MGI
Primary source
MGI:MGI:1924059
See related
Ensembl:ENSMUSG00000037905 AllianceGenome:MGI:1924059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410150I18Rik
Summary
Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in gut; liver; lung; metanephros; and submandibular gland primordium. Orthologous to human BRI3BP (BRI3 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 8.3), duodenum adult (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bri3bp in Genome Data Viewer
Location:
5 G1.1; 5 64.21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125518632..125537949)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125441568..125460885)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3623 Neighboring gene nuclear encoded tRNA alanine 5 (anticodon TGC) Neighboring gene DEAH-box helicase 37 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:125921729-125921912 Neighboring gene STARR-positive B cell enhancer ABC_E853 Neighboring gene predicted gene, 40325 Neighboring gene STARR-positive B cell enhancer ABC_E6383 Neighboring gene STARR-positive B cell enhancer ABC_E6384 Neighboring gene acetoacetyl-CoA synthetase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  2. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BRI3-binding protein
Names
I3-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359486.1 → NP_001346415.1  BRI3-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC138613
    UniProtKB/TrEMBL
    A0A0G2JGE0
    Related
    ENSMUSP00000143530.2, ENSMUST00000198811.2
    Conserved Domains (1) summary
    pfam14965
    Location:66 → 111
    BRI3BP; Negative regulator of p53/TP53

  2. NM_029752.2 → NP_084028.1  BRI3-binding protein isoform 1

    See identical proteins and their annotated locations for NP_084028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK143538, AK164638, BB618776, BY152144, CD742489
    Consensus CDS
    CCDS19686.1
    UniProtKB/Swiss-Prot
    Q8BXP1, Q8BXV2, Q9CWE5
    Related
    ENSMUSP00000037609.10, ENSMUST00000049040.14
    Conserved Domains (1) summary
    pfam14965
    Location:66 → 241
    BRI3BP; Negative regulator of p53/TP53

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    125518632..125537949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXV2.1 GenPept UniProtKB/Swiss-Prot:Q8BXV2

Gene LinkOut

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