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Csta2 cystatin A family member 2 [ Mus musculus (house mouse) ]

Gene ID: 76770, updated on 2-Nov-2024

Summary

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Official Symbol
Csta2provided by MGI
Official Full Name
cystatin A family member 2provided by MGI
Primary source
MGI:MGI:1924020
See related
Ensembl:ENSMUSG00000095620 AllianceGenome:MGI:1924020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010005H15Rik
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular components, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver E18 (RPKM 59.3) See more
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Genomic context

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See Csta2 in Genome Data Viewer
Location:
16 B3; 16 25.44 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36041932..36077813)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36221562..36257447)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 10913 Neighboring gene cystatin A family member 3 Neighboring gene STARR-seq mESC enhancer starr_40762 Neighboring gene predicted gene, 24569 Neighboring gene stefin A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
  5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide cross-linking ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cornified envelope ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of peptidase inhibitor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Cystatin-A-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384090.1 → NP_001371019.1  Cystatin-A-like

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT033776
    UniProtKB/TrEMBL
    Q9D8D6
    Related
    ENSMUSP00000067712.7, ENSMUST00000063539.7
    Conserved Domains (1) summary
    pfam00031
    Location:4 → 90
    Cystatin; Cystatin domain

  2. NM_029733.3 → NP_084009.1  Cystatin-A-like

    See identical proteins and their annotated locations for NP_084009.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC125422
    Consensus CDS
    CCDS37330.1
    UniProtKB/TrEMBL
    Q9D8D6
    Related
    ENSMUSP00000140745.2, ENSMUST00000187183.7
    Conserved Domains (1) summary
    pfam00031
    Location:4 → 90
    Cystatin; Cystatin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36041932..36077813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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