ST14 ST14 transmembrane serine protease matriptase [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: ST14
Gene description: ST14 transmembrane serine protease matriptase
See related: BGD:BT13879; Ensembl:ENSBTAG00000019712
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (36351360..36389421)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_21455-21456:1032968596:1 (e-PCR)
- UniSTS:268552

BARC0048 (e-PCR)
- UniSTS:255328

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in acrosome reaction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: suppressor of tumorigenicity 14 protein homolog

Names: serine protease 14; suppression of tumorigenicity 14 (colon carcinoma); suppressor of tumorigenicity protein 14

NP_001070006.1

EC 3.4.21.109

XP_024843118.2

EC 3.4.21.109

XP_059739024.1

EC 3.4.21.109

XP_059739025.1

EC 3.4.21.109

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076538.1 → NP_001070006.1 suppressor of tumorigenicity 14 protein homolog

See identical proteins and their annotated locations for NP_001070006.1

Status: PROVISIONAL

Source sequence(s)

BC122638

UniProtKB/Swiss-Prot

Q0IIH7

UniProtKB/TrEMBL

F1N4X7

Related

ENSBTAP00000026272.5, ENSBTAT00000026272.6

Conserved Domains (5) summary

smart00020
Location:614 → 849

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:340 → 444

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:525 → 559

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:615 → 850

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:88 → 162

SEA; SEA domain