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ZNF222 zinc finger protein 222 [ Homo sapiens (human) ]

Gene ID: 7673, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF222provided by HGNC
Official Full Name
zinc finger protein 222provided by HGNC
Primary source
HGNC:HGNC:13015
See related
Ensembl:ENSG00000159885 MIM:617357; AllianceGenome:HGNC:13015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.6), urinary bladder (RPKM 1.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44025379..44033110)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46848287..46856014)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44529531..44537263)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14748 Neighboring gene zinc finger protein 230 Neighboring gene ZNF222 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44555855-44556356 Neighboring gene zinc finger protein 223 Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The identification and characterization of KRAB-domain-containing zinc finger proteins. Constantinou-Deltas CD, et al. Genomics, 1992 Mar. PMID 1559709
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  3. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 222

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129996.2 → NP_001123468.1  zinc finger protein 222 isoform 1

    See identical proteins and their annotated locations for NP_001123468.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    BC030261, DB185422
    Consensus CDS
    CCDS46098.1
    UniProtKB/Swiss-Prot
    Q9UK12
    Related
    ENSP00000375822.2, ENST00000391960.4
    Conserved Domains (5) summary
    smart00349
    Location:17 → 76
    KRAB; krueppel associated box
    COG5048
    Location:183 → 315
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:17 → 56
    KRAB; KRAB box
    pfam13465
    Location:284 → 306
    zf-H2C2_2; Zinc-finger double domain

  2. NM_013360.3 → NP_037492.2  zinc finger protein 222 isoform 2

    See identical proteins and their annotated locations for NP_037492.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2 which is 40 aa shorter than isoform 1.
    Source sequence(s)
    AF187988, BC030261
    Consensus CDS
    CCDS33045.1
    UniProtKB/Swiss-Prot
    G5E9B9, Q8N6G7, Q9P1U5, Q9UK12
    Related
    ENSP00000187879.6, ENST00000187879.12
    Conserved Domains (4) summary
    smart00349
    Location:8 → 53
    KRAB; krueppel associated box
    sd00017
    Location:147 → 167
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:244 → 266
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44025379..44033110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259208.4 → XP_005259265.1  zinc finger protein 222 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    sd00017
    Location:178 → 198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:275 → 297
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017027237.2 → XP_016882726.1  zinc finger protein 222 isoform X3

  3. XM_005259209.4 → XP_005259266.1  zinc finger protein 222 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:17 → 62
    KRAB; krueppel associated box
    sd00017
    Location:156 → 176
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:17 → 56
    KRAB; KRAB box
    pfam13465
    Location:253 → 275
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46848287..46856014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321998.1 → XP_054177973.1  zinc finger protein 222 isoform X1

  2. XM_054322000.1 → XP_054177975.1  zinc finger protein 222 isoform X3

  3. XM_054321999.1 → XP_054177974.1  zinc finger protein 222 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UK12.2 GenPept UniProtKB/Swiss-Prot:Q9UK12

Gene LinkOut

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