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Lrmda leucine rich melanocyte differentiation associated [ Mus musculus (house mouse) ]

Gene ID: 76633, updated on 2-Nov-2024

Summary

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Official Symbol
Lrmdaprovided by MGI
Official Full Name
leucine rich melanocyte differentiation associatedprovided by MGI
Primary source
MGI:MGI:1923883
See related
Ensembl:ENSMUSG00000063458 AllianceGenome:MGI:1923883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700112E06Rik; 2700009F18Rik
Summary
Predicted to be involved in melanocyte differentiation. Is expressed in embryo. Human ortholog(s) of this gene implicated in oculocutaneous albinism type VII. Orthologous to human LRMDA (leucine rich melanocyte differentiation associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Lrmda in Genome Data Viewer
Location:
14 A3; 14 12.03 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (22069567..23106161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (22019504..23056093)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330001L22 gene Neighboring gene VISTA enhancer mm414 Neighboring gene predicted gene, 41106 Neighboring gene predicted gene, 41107 Neighboring gene STARR-seq mESC enhancer starr_36161 Neighboring gene RIKEN cDNA 4930405A10 gene Neighboring gene predicted gene, 53836 Neighboring gene STARR-seq mESC enhancer starr_36162 Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36163 Neighboring gene STARR-seq mESC enhancer starr_36164 Neighboring gene STARR-seq mESC enhancer starr_36166 Neighboring gene STARR-seq mESC enhancer starr_36167 Neighboring gene predicted gene, 30926 Neighboring gene predicted gene 7473 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene predicted gene, 30783 Neighboring gene predicted gene, 53835 Neighboring gene STARR-seq mESC enhancer starr_36168 Neighboring gene STARR-seq mESC enhancer starr_36169 Neighboring gene predicted gene 10248 Neighboring gene STARR-seq mESC enhancer starr_36171 Neighboring gene STARR-seq mESC enhancer starr_36172 Neighboring gene STARR-seq mESC enhancer starr_36173 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, alpha member 1 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene predicted gene, 53837

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells. Guo YY, et al. Adv Sci (Weinh), 2022 Dec. PMID 36261399, Free PMC Article
  2. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca[2+] -LRMDA Axis in Myeloid Cells.
    Title: The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in melanocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in melanocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
leucine-rich melanocyte differentiation-associated protein
Names
leucine-rich repeat-containing protein C10orf11 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028275.1 → NP_082551.1  leucine-rich melanocyte differentiation-associated protein

    See identical proteins and their annotated locations for NP_082551.1

    Status: VALIDATED

    Source sequence(s)
    AK007175, BY516672
    Consensus CDS
    CCDS49415.1
    UniProtKB/Swiss-Prot
    Q9D9B4
    Related
    ENSMUSP00000075065.5, ENSMUST00000075639.11
    Conserved Domains (4) summary
    cd00116
    Location:27 → 111
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:34 → 54
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:54 → 93
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:53 → 112
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    22069567..23106161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519679.5 → XP_006519742.1  leucine-rich melanocyte differentiation-associated protein isoform X5

    Conserved Domains (1) summary
    pfam14580
    Location:44 → 70
    LRR_9; Leucine-rich repeat

  2. XM_006519680.5 → XP_006519743.1  leucine-rich melanocyte differentiation-associated protein isoform X6

    UniProtKB/TrEMBL
    E0CYG4
    Conserved Domains (1) summary
    pfam14580
    Location:44 → 70
    LRR_9; Leucine-rich repeat

  3. XM_036158898.1 → XP_036014791.1  leucine-rich melanocyte differentiation-associated protein isoform X2

    Conserved Domains (2) summary
    sd00031
    Location:34 → 54
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:23 → 159
    LRR_9; Leucine-rich repeat

  4. XM_006519676.5 → XP_006519739.1  leucine-rich melanocyte differentiation-associated protein isoform X1

    Conserved Domains (2) summary
    sd00031
    Location:34 → 54
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:21 → 159
    LRR_9; Leucine-rich repeat

  5. XM_036158899.1 → XP_036014792.1  leucine-rich melanocyte differentiation-associated protein isoform X3

    UniProtKB/TrEMBL
    E0CZ28
    Related
    ENSMUSP00000125751.2, ENSMUST00000159777.8
    Conserved Domains (2) summary
    sd00031
    Location:34 → 54
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:23 → 159
    LRR_9; Leucine-rich repeat

  6. XM_006519678.4 → XP_006519741.1  leucine-rich melanocyte differentiation-associated protein isoform X4

    Conserved Domains (2) summary
    sd00031
    Location:13 → 34
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:1 → 117
    LRR_9; Leucine-rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9B4.1 GenPept UniProtKB/Swiss-Prot:Q9D9B4

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