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Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 [ Mus musculus (house mouse) ]

Gene ID: 76594, updated on 9-May-2024

Summary

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Official Symbol
Dnajc18provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C18provided by MGI
Primary source
MGI:MGI:1923844
See related
Ensembl:ENSMUSG00000024350 AllianceGenome:MGI:1923844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700075B01Rik
Summary
Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; genitourinary system; gut gland; sensory organ; and skeleton. Orthologous to human DNAJC18 (DnaJ heat shock protein family (Hsp40) member C18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 10.7), frontal lobe adult (RPKM 10.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc18 in Genome Data Viewer
Location:
18 B2; 18 19.21 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35804156..35841467, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35671103..35708418, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene proline rich basic protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7578 Neighboring gene spermatogenesis associated 24 Neighboring gene STARR-seq mESC enhancer starr_44246 Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene STARR-positive B cell enhancer mm9_chr18:35889997-35890297 Neighboring gene small integral membrane protein 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 18
Names
DnaJ (Hsp40) homolog, subfamily C, member 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029669.4 → NP_083945.1  dnaJ homolog subfamily C member 18

    See identical proteins and their annotated locations for NP_083945.1

    Status: VALIDATED

    Source sequence(s)
    AC121821, AC132837
    Consensus CDS
    CCDS29148.1
    UniProtKB/Swiss-Prot
    Q8R371, Q9CZJ9
    Related
    ENSMUSP00000025208.6, ENSMUST00000025208.7
    Conserved Domains (2) summary
    PRK14298
    Location:81 → 182
    PRK14298; chaperone protein DnaJ; Provisional
    pfam09320
    Location:250 → 349
    DUF1977; Domain of unknown function (DUF1977)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35804156..35841467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161306.1 → XP_036017199.1  dnaJ homolog subfamily C member 18 isoform X2

    Conserved Domains (2) summary
    PRK14298
    Location:40 → 141
    PRK14298; chaperone protein DnaJ; Provisional
    pfam09320
    Location:208 → 308
    DUF1977; Domain of unknown function (DUF1977)

  2. XM_006526345.4 → XP_006526408.1  dnaJ homolog subfamily C member 18 isoform X1

    See identical proteins and their annotated locations for XP_006526408.1

    UniProtKB/Swiss-Prot
    Q8R371, Q9CZJ9
    Conserved Domains (2) summary
    PRK14298
    Location:81 → 182
    PRK14298; chaperone protein DnaJ; Provisional
    pfam09320
    Location:250 → 349
    DUF1977; Domain of unknown function (DUF1977)

  3. XM_006526343.4 → XP_006526406.1  dnaJ homolog subfamily C member 18 isoform X1

    See identical proteins and their annotated locations for XP_006526406.1

    UniProtKB/Swiss-Prot
    Q8R371, Q9CZJ9
    Conserved Domains (2) summary
    PRK14298
    Location:81 → 182
    PRK14298; chaperone protein DnaJ; Provisional
    pfam09320
    Location:250 → 349
    DUF1977; Domain of unknown function (DUF1977)

  4. XM_006526344.4 → XP_006526407.1  dnaJ homolog subfamily C member 18 isoform X1

    See identical proteins and their annotated locations for XP_006526407.1

    UniProtKB/Swiss-Prot
    Q8R371, Q9CZJ9
    Conserved Domains (2) summary
    PRK14298
    Location:81 → 182
    PRK14298; chaperone protein DnaJ; Provisional
    pfam09320
    Location:250 → 349
    DUF1977; Domain of unknown function (DUF1977)

  5. XM_006526346.4 → XP_006526409.1  dnaJ homolog subfamily C member 18 isoform X2

    Conserved Domains (2) summary
    PRK14298
    Location:40 → 141
    PRK14298; chaperone protein DnaJ; Provisional
    pfam09320
    Location:208 → 308
    DUF1977; Domain of unknown function (DUF1977)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZJ9.1 GenPept UniProtKB/Swiss-Prot:Q9CZJ9

Gene LinkOut

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