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Spatc1l spermatogenesis and centriole associated 1 like [ Mus musculus (house mouse) ]

Gene ID: 76573, updated on 2-Nov-2024

Summary

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Official Symbol
Spatc1lprovided by MGI
Official Full Name
spermatogenesis and centriole associated 1 likeprovided by MGI
Primary source
MGI:MGI:1923823
See related
Ensembl:ENSMUSG00000009115 AllianceGenome:MGI:1923823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700022B01Rik; 1700027D21Rik
Summary
Enables protein kinase A regulatory subunit binding activity. Acts upstream of or within several processes, including actin polymerization or depolymerization; positive regulation of cAMP-dependent protein kinase activity; and positive regulation of cAMP/PKA signal transduction. Located in centrosome and sperm head-tail coupling apparatus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human SPATC1L (spermatogenesis and centriole associated 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 108.1) See more
Orthologs
human all
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Genomic context

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See Spatc1l in Genome Data Viewer
Location:
10 C1; 10 39.2 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76394180..76406035)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76561993..76570201)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ybeY metallopeptidase Neighboring gene STARR-seq mESC enhancer starr_27182 Neighboring gene minichromosome maintenance complex component 3 associated protein Neighboring gene STARR-positive B cell enhancer ABC_E6874 Neighboring gene RIKEN cDNA 4930483K19 gene Neighboring gene lanosterol synthase Neighboring gene predicted gene 15343 Neighboring gene formiminotransferase cyclodeaminase Neighboring gene collagen, type VI, alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SPATC1L maintains the integrity of the sperm head-tail junction. Kim J, et al. EMBO Rep, 2018 Sep. PMID 30026308, Free PMC Article
  2. Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. Hong S, et al. J Biol Chem, 2005 Mar 4. PMID 15613475
  3. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Endoh-Yamagami S, et al. Dev Biol, 2010 Apr 1. PMID 20096683
  4. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cAMP/PKA signal transduction IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm head-tail coupling apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm head-tail coupling apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
speriolin-like protein
Names
spermatogenesis and centriole-associated protein 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359186.1 → NP_001346115.1  speriolin-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK006232, AK006410, BX636056
    Consensus CDS
    CCDS88029.1
    UniProtKB/TrEMBL
    D3Z7D4
    Related
    ENSMUSP00000101054.2, ENSMUST00000105414.2
    Conserved Domains (1) summary
    pfam15058
    Location:5 → 155
    Speriolin_N; Speriolin N terminus

  2. NM_029661.1 → NP_083937.1  speriolin-like protein isoform 1

    See identical proteins and their annotated locations for NP_083937.1

    Status: VALIDATED

    Source sequence(s)
    AK006410
    Consensus CDS
    CCDS23949.1
    UniProtKB/Swiss-Prot
    B2RW50, Q9D9W0
    Related
    ENSMUSP00000009259.5, ENSMUST00000009259.5
    Conserved Domains (2) summary
    pfam15058
    Location:5 → 155
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:197 → 342
    Speriolin_C; Speriolin C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    76394180..76406035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314142.3 → XP_017169631.1  speriolin-like protein isoform X2

    Conserved Domains (2) summary
    pfam15058
    Location:1 → 41
    Speriolin_N; Speriolin N-terminus
    pfam15059
    Location:83 → 228
    Speriolin_C; Speriolin C-terminus

  2. XM_006514279.3 → XP_006514342.1  speriolin-like protein isoform X1

    Conserved Domains (2) summary
    pfam15058
    Location:3 → 89
    Speriolin_N; Speriolin N-terminus
    pfam15059
    Location:131 → 276
    Speriolin_C; Speriolin C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9W0.1 GenPept UniProtKB/Swiss-Prot:Q9D9W0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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