Rflnb refilin B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rflnbprovided by MGI
Official Full Name: refilin Bprovided by MGI
Primary source: MGI:MGI:1923816
See related: Ensembl:ENSMUSG00000020846 AllianceGenome:MGI:1923816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cfm; Fam101b; RefilinB; 1500005K14Rik
Summary: Predicted to enable filamin binding activity. Acts upstream of or within several processes, including actin filament bundle organization; negative regulation of bone mineralization involved in bone maturation; and negative regulation of chondrocyte development. Located in actin filament bundle. Is expressed in several structures, including 1st branchial arch; embryo ectoderm; genital tubercle; lung; and occipital myotome. Orthologous to human RFLNB (refilin B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in stomach adult (RPKM 30.0), colon adult (RPKM 25.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75910020..75918608, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (76019194..76027782, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Filamin a, b-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeleton.
Title: Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

1500005K14Rik (e-PCR), detects polymorphism
- UniSTS:469787

1500005K14Rik (e-PCR), detects polymorphism
- UniSTS:469788

NoName (e-PCR)
- UniSTS:236644

D11Jcs9 (e-PCR), detects polymorphism
- UniSTS:461965

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables filamin binding	IBA Inferred from Biological aspect of Ancestor more info
enables filamin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament bundle organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial to mesenchymal transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of bone mineralization involved in bone maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of bone mineralization involved in bone maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of chondrocyte development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of chondrocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in skeletal system morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament bundle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: refilin-B

Names: family with sequence similarity 101, member B; filamin-interacting protein FAM101B; protein FAM101B; regulator of filamin protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.