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Smim45 small integral membrane protein 45 [ Mus musculus (house mouse) ]

Gene ID: 76505, updated on 2-Nov-2024

Summary

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Official Symbol
Smim45provided by MGI
Official Full Name
small integral membrane protein 45provided by MGI
Primary source
MGI:MGI:1923755
See related
Ensembl:ENSMUSG00000068099 AllianceGenome:MGI:1923755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500009C09Rik
Summary
Predicted to be involved in neuron maturation. Predicted to be located in cytoplasm and nucleus. Is expressed in cerebral cortex. Orthologous to human SMIM45 (small integral membrane protein 45). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 39.0), frontal lobe adult (RPKM 31.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Smim45 in Genome Data Viewer
Location:
15 E1; 15 38.56 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82136673..82144947)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82252472..82260746)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 13c Neighboring gene centromere protein M Neighboring gene STARR-positive B cell enhancer ABC_E8601 Neighboring gene STARR-seq mESC enhancer starr_39290 Neighboring gene predicted gene, 52180 Neighboring gene septin 3 Neighboring gene STARR-seq mESC enhancer starr_39292 Neighboring gene WBP2 N-terminal like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in neuron maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small integral membrane protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395955.1 → NP_001382884.1  small integral membrane protein 45

    Status: VALIDATED

    Source sequence(s)
    AK005178, BC094356
    UniProtKB/TrEMBL
    D3YWK9, D3YYW9
    Related
    ENSMUSP00000120070.2, ENSMUST00000143238.2
    Conserved Domains (1) summary
    PLN02960
    Location:29 → 52
    PLN02960; alpha-amylase

  2. NM_001395956.1 → NP_001382885.1  small integral membrane protein 45

    Status: VALIDATED

    Source sequence(s)
    AC104325
    UniProtKB/TrEMBL
    D3YWK9, D3YYW9
    Related
    ENSMUSP00000115748.3, ENSMUST00000136948.3
    Conserved Domains (1) summary
    PLN02960
    Location:29 → 52
    PLN02960; alpha-amylase

RNA

  1. NR_172943.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104325

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82136673..82144947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_037697.2: Suppressed sequence

    Description
    NR_037697.2: This RefSeq was removed because it is now thought that this gene does encode a protein.

  2. NR_037698.2: Suppressed sequence

    Description
    NR_037698.2: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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