U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF74 zinc finger protein 74 [ Homo sapiens (human) ]

Gene ID: 7625, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF74provided by HGNC
Official Full Name
zinc finger protein 74provided by HGNC
Primary source
HGNC:HGNC:13144
See related
Ensembl:ENSG00000185252 MIM:194548; AllianceGenome:HGNC:13144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COS52; hZNF7; ZFP520; ZNF520
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 2.9), endometrium (RPKM 2.2) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF74 in Genome Data Viewer
Location:
22q11.21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20394151..20408455)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20798473..20812756)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20748441..20762745)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905153 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20708428-20708649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20715037-20715538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20715539-20716038 Neighboring gene ubiquitin specific peptidase 41, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20747551-20748540 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62654 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62657 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20764690-20764912 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62670 Neighboring gene RNA, U6 small nuclear 225, pseudogene Neighboring gene VISTA enhancer hs1620 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20783264-20783430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20784487-20785326 Neighboring gene scavenger receptor class F member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia. Ravassard P, et al. Genomics, 1999 Nov 15. PMID 10585771
  2. The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix. Grondin B, et al. J Biol Chem, 1996 Jun 28. PMID 8663113
  3. Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome. Aubry M, et al. Hum Mol Genet, 1993 Oct. PMID 8268910
  4. Association of ZNF74 gene genotypes with age-at-onset of schizophrenia. Takase K, et al. Schizophr Res, 2001 Dec 1. PMID 11705709
  5. Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning. Côté F, et al. DNA Cell Biol, 2001 Mar. PMID 11313019

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of ZNF74 gene genotypes with age-at-onset of schizophrenia.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 74
Names
zinc finger protein 520

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256523.2 → NP_001243452.1  zinc finger protein 74 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a frameshift in the remaining coding region, compared to variant 1. The encoded isoform (b) shares the same N-terminus but is otherwise distinct and shorter, compared to isoform a.
    Source sequence(s)
    AC007731, BC013395, BC013741, BG912037, DA791304
    Consensus CDS
    CCDS58794.1
    UniProtKB/Swiss-Prot
    Q16587
    Related
    ENSP00000384750.3, ENST00000403682.7

  2. NM_001256524.2 → NP_001243453.1  zinc finger protein 74 isoform a

    See identical proteins and their annotated locations for NP_001243453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AC007731, AK291358, BC013395, BC056902, BG912037, DA791304
    Consensus CDS
    CCDS42982.1
    UniProtKB/Swiss-Prot
    B5MCE3, B7Z5Y2, Q16587, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
    UniProtKB/TrEMBL
    A8K5P3
    Related
    ENSP00000483077.1, ENST00000611540.4
    Conserved Domains (4) summary
    smart00349
    Location:43 → 103
    KRAB; krueppel associated box
    COG5048
    Location:331 → 511
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:306 → 326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:514 → 539
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001256525.2 → NP_001243454.1  zinc finger protein 74 isoform c

    See identical proteins and their annotated locations for NP_001243454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC007731, BC013395, BC048295, BG912037, DA791304
    UniProtKB/TrEMBL
    Q05BG0
    Conserved Domains (4) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:260 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:235 → 255
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:387 → 412
    zf-H2C2_2; Zinc-finger double domain

  4. NM_003426.4 → NP_003417.2  zinc finger protein 74 isoform a

    See identical proteins and their annotated locations for NP_003417.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 3 encode isoform a.
    Source sequence(s)
    AC007731, BC013395, BC056902, BG912037, DA791304
    Consensus CDS
    CCDS42982.1
    UniProtKB/Swiss-Prot
    B5MCE3, B7Z5Y2, Q16587, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
    UniProtKB/TrEMBL
    A8K5P3
    Related
    ENSP00000383301.2, ENST00000400451.7
    Conserved Domains (4) summary
    smart00349
    Location:43 → 103
    KRAB; krueppel associated box
    COG5048
    Location:331 → 511
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:306 → 326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:514 → 539
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_046282.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an additional exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB209663, AC007731, BC013395, BG912037, DA791304
    Related
    ENST00000437275.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20394151..20408455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20798473..20812756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16587.3 GenPept UniProtKB/Swiss-Prot:Q16587

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous