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ZNF70 zinc finger protein 70 [ Homo sapiens (human) ]

Gene ID: 7621, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF70provided by HGNC
Official Full Name
zinc finger protein 70provided by HGNC
Primary source
HGNC:HGNC:13140
See related
Ensembl:ENSG00000187792 MIM:194544; AllianceGenome:HGNC:13140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cos17
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 2.8), thyroid (RPKM 1.7) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZNF70 in Genome Data Viewer
Location:
22q11.23
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23738682..23751112, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24185879..24199262, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24080869..24093299, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene GUSB pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24037607-24038107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18756 Neighboring gene ral guanine nucleotide dissociation stimulator like 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24059101-24059740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24059741-24060380 Neighboring gene uncharacterized LOC124905088 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24087516-24088016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24088017-24088517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24093057-24093732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24095085-24095758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24096535-24097035 Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24107697-24108496 Neighboring gene chromosome 22 open reading frame 15 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation. Han GL, et al. Anticancer Drugs, 2020 Mar. PMID 32053575
  2. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Aubry M, et al. Genomics, 1992 Jul. PMID 1639391
  3. ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression. Watanabe K, et al. Biochem Biophys Res Commun, 2016 Sep 2. PMID 27353377
  4. A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802, Free PMC Article
  5. Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Seo HG, et al. Cell Death Dis, 2020 Sep 29. PMID 32994395, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF70 regulates IL-1beta secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer.
    Title: ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer.
  2. miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation.
    Title: miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation.
  3. We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee
    Title: ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44547, MGC48959

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in megasporocyte nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 70
Names
zinc finger protein N27C7-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021916.4 → NP_068735.1  zinc finger protein 70

    See identical proteins and their annotated locations for NP_068735.1

    Status: VALIDATED

    Source sequence(s)
    AK122721, AP000348, BC040161
    Consensus CDS
    CCDS13812.1
    UniProtKB/Swiss-Prot
    Q9UC06
    Related
    ENSP00000339314.3, ENST00000341976.5
    Conserved Domains (2) summary
    COG5048
    Location:138 → 442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    23738682..23751112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441490.1 → XP_047297446.1  zinc finger protein 70 isoform X1

    UniProtKB/Swiss-Prot
    Q9UC06

  2. XM_024452271.2 → XP_024308039.1  zinc finger protein 70 isoform X1

    UniProtKB/Swiss-Prot
    Q9UC06
    Conserved Domains (2) summary
    COG5048
    Location:138 → 442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_024452270.2 → XP_024308038.1  zinc finger protein 70 isoform X1

    UniProtKB/Swiss-Prot
    Q9UC06
    Conserved Domains (2) summary
    COG5048
    Location:138 → 442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_024452269.2 → XP_024308037.1  zinc finger protein 70 isoform X1

    UniProtKB/Swiss-Prot
    Q9UC06
    Conserved Domains (2) summary
    COG5048
    Location:138 → 442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    24185879..24199262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325902.1 → XP_054181877.1  zinc finger protein 70 isoform X1

    UniProtKB/Swiss-Prot
    Q9UC06

  2. XM_054325904.1 → XP_054181879.1  zinc finger protein 70 isoform X1

    UniProtKB/Swiss-Prot
    Q9UC06

  3. XM_054325903.1 → XP_054181878.1  zinc finger protein 70 isoform X1

    UniProtKB/Swiss-Prot
    Q9UC06
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UC06.2 GenPept UniProtKB/Swiss-Prot:Q9UC06

Gene LinkOut

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