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Arl5b ADP-ribosylation factor-like 5B [ Mus musculus (house mouse) ]

Gene ID: 75869, updated on 11-Apr-2024

Summary

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Official Symbol
Arl5bprovided by MGI
Official Full Name
ADP-ribosylation factor-like 5Bprovided by MGI
Primary source
MGI:MGI:1923119
See related
Ensembl:ENSMUSG00000017418 AllianceGenome:MGI:1923119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arl8; 4930587A11Rik
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Is expressed in testis. Orthologous to human ARL5B (ADP ribosylation factor like GTPase 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 9.2), whole brain E14.5 (RPKM 7.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Arl5b in Genome Data Viewer
Location:
2 A2; 2 10.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (15060066..15087267)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (15055252..15082456)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 2 subunit Neighboring gene STARR-seq mESC enhancer starr_03734 Neighboring gene TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_03735 Neighboring gene STARR-positive B cell enhancer ABC_E7794 Neighboring gene STARR-seq mESC enhancer starr_03736 Neighboring gene NOL1/NOP2/Sun domain family member 6 Neighboring gene STARR-seq mESC enhancer starr_03737 Neighboring gene STARR-seq mESC enhancer starr_03738 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene Neighboring gene STARR-seq mESC enhancer starr_03739 Neighboring gene STARR-seq mESC enhancer starr_03740 Neighboring gene STARR-seq mESC enhancer starr_03741 Neighboring gene STARR-seq mESC enhancer starr_03742 Neighboring gene predicted gene 13367

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B. Kitai Y, et al. J Biol Chem, 2015 Jan 9. PMID 25451939, Free PMC Article
  2. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. Sebald E, et al. Gene, 2003 Jun 5. PMID 12853149
  3. Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Vergnes L, et al. Cell Metab, 2013 Jun 4. PMID 23747249, Free PMC Article
  4. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results, therefore, suggest that Arl5B is a negative regulator for MDA5.
    Title: Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.
  2. The expression pattern of the mouse ortholog Arl8 revealed differential tissue expression and an alternate transcript was seen in brain that was age-dependent.
    Title: Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 5B
Names
ADP-ribosylation factor-like 8
ADP-ribosylation factor-like protein 8
ADP-ribosylation-like factor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029466.5 → NP_083742.3  ADP-ribosylation factor-like protein 5B

    Status: VALIDATED

    Source sequence(s)
    AL929268
    Consensus CDS
    CCDS15704.2
    UniProtKB/Swiss-Prot
    Q8BFU5, Q9D4P0
    UniProtKB/TrEMBL
    Q8BLF9
    Related
    ENSMUSP00000069725.5, ENSMUST00000069870.11
    Conserved Domains (1) summary
    cd04153
    Location:3 → 175
    Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    15060066..15087267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319316.3 → XP_017174805.1  ADP-ribosylation factor-like protein 5B isoform X1

    UniProtKB/TrEMBL
    Q8BLF9
    Conserved Domains (1) summary
    cl38936
    Location:1 → 138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4P0.3 GenPept UniProtKB/Swiss-Prot:Q9D4P0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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