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Pnpla5 patatin-like phospholipase domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 75772, updated on 28-Oct-2024

Summary

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Official Symbol
Pnpla5provided by MGI
Official Full Name
patatin-like phospholipase domain containing 5provided by MGI
Primary source
MGI:MGI:1923022
See related
Ensembl:ENSMUSG00000018868 AllianceGenome:MGI:1923022
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GS2L; 4833426H19Rik
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA5 (patatin like phospholipase domain containing 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Pnpla5 in Genome Data Viewer
Location:
15 E2; 15 39.78 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83996631..84007567, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (84112621..84123175, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 6 Neighboring gene ribosomal protein L31, pseudogene 22 Neighboring gene sulfotransferase family 4A, member 1 Neighboring gene predicted gene, 46526 Neighboring gene predicted gene, 33432 Neighboring gene STARR-seq mESC enhancer starr_39351 Neighboring gene predicted gene, 33530

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC130406, MGC130407

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
patatin-like phospholipase domain-containing protein 5
NP_083703.1
XP_036015516.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029427.1 → NP_083703.1  patatin-like phospholipase domain-containing protein 5

    See identical proteins and their annotated locations for NP_083703.1

    Status: PROVISIONAL

    Source sequence(s)
    BC109360
    Consensus CDS
    CCDS49685.1
    UniProtKB/Swiss-Prot
    Q32LZ8, Q9D603
    Related
    ENSMUSP00000019012.4, ENSMUST00000019012.4
    Conserved Domains (1) summary
    cd07223
    Location:1 → 403
    Pat_PNPLA5-mammals; Patatin-like phospholipase domain containing protein 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83996631..84007567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159623.1 → XP_036015516.1  patatin-like phospholipase domain-containing protein 5 isoform X1

    Related
    ENSMUSP00000155268.2, ENSMUST00000230566.2
    Conserved Domains (1) summary
    cd07223
    Location:1 → 403
    Pat_PNPLA5-mammals; Patatin-like phospholipase domain containing protein 5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32LZ8.1 GenPept UniProtKB/Swiss-Prot:Q32LZ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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