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ZNF28 zinc finger protein 28 [ Homo sapiens (human) ]

Gene ID: 7576, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF28provided by HGNC
Official Full Name
zinc finger protein 28provided by HGNC
Primary source
HGNC:HGNC:13073
See related
Ensembl:ENSG00000198538 MIM:620466; AllianceGenome:HGNC:13073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX24
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.8), colon (RPKM 1.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52797408..52821633, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55881862..55905963, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53300661..53324886, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 611 Neighboring gene uncharacterized LOC124904760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53238285-53239270 Neighboring gene uncharacterized LOC105372452 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53259364-53260079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53263091-53263641 Neighboring gene zinc finger protein 600 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53285228-53285408 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53287129-53287305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289004-53289862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289863-53290720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53293023-53293553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53294085-53294614 Neighboring gene PABPN1 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53324831-53325332 Neighboring gene zinc finger protein 468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15057 Neighboring gene zinc finger protein 320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53379555-53380056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. Rousseau-Merck MF, et al. Hum Genet, 1993 Dec. PMID 8262519
  2. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
  3. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  4. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781D0275

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 28
Names
zinc finger protein KOX24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369761.1 → NP_001356690.1  zinc finger protein 28 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Consensus CDS
    CCDS92677.1
    UniProtKB/TrEMBL
    M0QXU3
    Related
    ENSP00000469381.1, ENST00000594602.5
    Conserved Domains (1) summary
    smart00349
    Location:8 → 54
    KRAB; krueppel associated box

  2. NM_001369762.1 → NP_001356691.1  zinc finger protein 28 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Consensus CDS
    CCDS92676.1
    Related
    ENSP00000375661.2, ENST00000391783.6
    Conserved Domains (3) summary
    COG5048
    Location:300 → 661
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:211 → 321
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001369763.1 → NP_001356692.1  zinc finger protein 28 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Conserved Domains (3) summary
    COG5048
    Location:350 → 711
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:261 → 371
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550 → 570
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001369764.1 → NP_001356693.1  zinc finger protein 28 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Conserved Domains (4) summary
    COG5048
    Location:339 → 700
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:250 → 360
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:539 → 559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  5. NM_001369765.1 → NP_001356694.1  zinc finger protein 28 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Conserved Domains (3) summary
    COG5048
    Location:317 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:228 → 338
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001369766.1 → NP_001356695.1  zinc finger protein 28 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Conserved Domains (1) summary
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  7. NM_001369767.1 → NP_001356696.1  zinc finger protein 28 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008813

  8. NM_001369768.1 → NP_001356697.1  zinc finger protein 28 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC008813, BC070146
    UniProtKB/TrEMBL
    Q6NSH2
    Related
    ENST00000464469.2
    Conserved Domains (1) summary
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  9. NM_006969.5 → NP_008900.3  zinc finger protein 28 isoform 1

    See identical proteins and their annotated locations for NP_008900.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008813
    Consensus CDS
    CCDS33093.2
    UniProtKB/Swiss-Prot
    A8KAK9, B4E3G0, B9EIK7, P17035, Q5H9V1, Q5HYM9, Q6ZML9, Q6ZN56
    Related
    ENSP00000397693.2, ENST00000457749.7
    Conserved Domains (5) summary
    smart00349
    Location:8 → 48
    KRAB; krueppel associated box
    COG5048
    Location:267 → 655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553 → 573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:397 → 422
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_163139.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008813

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52797408..52821633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55881862..55905963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17035.5 GenPept UniProtKB/Swiss-Prot:P17035

Gene LinkOut

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