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Morc4 microrchidia 4 [ Mus musculus (house mouse) ]

Gene ID: 75746, updated on 2-Nov-2024

Summary

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Official Symbol
Morc4provided by MGI
Official Full Name
microrchidia 4provided by MGI
Primary source
MGI:MGI:1922996
See related
Ensembl:ENSMUSG00000031434 AllianceGenome:MGI:1922996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zcwcc2; 1600017G11Rik; 5630401M14Rik
Summary
Predicted to enable methylated histone binding activity. Predicted to be active in nucleoplasm. Is expressed in genitourinary system. Orthologous to human MORC4 (MORC family CW-type zinc finger 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 39.1), liver E18 (RPKM 16.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Morc4 in Genome Data Viewer
Location:
X F1; X 61.35 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (138722384..138772440, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139821635..139871692, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47999 Neighboring gene ripply transcriptional repressor 1 Neighboring gene claudin 2 Neighboring gene predicted gene, 52431 Neighboring gene NMD3 homolog pseudogene Neighboring gene RNA binding motif protein 41 Neighboring gene STARR-seq mESC enhancer starr_48000 Neighboring gene nucleoporin 62 C-terminal like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC107438

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MORC family CW-type zinc finger protein 4
Names
zinc finger CW-type coiled-coil domain protein 2
zinc finger, CW-type with coiled-coil domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193309.1 → NP_001180238.1  MORC family CW-type zinc finger protein 4 isoform A

    See identical proteins and their annotated locations for NP_001180238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longer isoform (A).
    Source sequence(s)
    AL672243
    Consensus CDS
    CCDS57777.1
    UniProtKB/Swiss-Prot
    A2RTG5, Q4KMM6, Q8BMD7, Q8BX95, Q9CS96
    UniProtKB/TrEMBL
    A2RSL2
    Related
    ENSMUSP00000084663.6, ENSMUST00000087401.12
    Conserved Domains (2) summary
    pfam07496
    Location:422 → 466
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:50 → 141
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

  2. NM_029413.4 → NP_083689.2  MORC family CW-type zinc finger protein 4 isoform B

    See identical proteins and their annotated locations for NP_083689.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform B) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AK032807, AL672243, BC132497
    Consensus CDS
    CCDS53203.1
    UniProtKB/TrEMBL
    A2RSL2
    Related
    ENSMUSP00000033811.8, ENSMUST00000033811.14
    Conserved Domains (2) summary
    pfam07496
    Location:422 → 466
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:50 → 141
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    138722384..138772440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528618.4 → XP_006528681.1  MORC family CW-type zinc finger protein 4 isoform X1

    UniProtKB/TrEMBL
    A2RSL2
    Conserved Domains (3) summary
    pfam07496
    Location:525 → 569
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:369 → 503
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    cl00075
    Location:142 → 259
    HATPase; Histidine kinase-like ATPase domain

  2. XM_006528619.5 → XP_006528682.1  MORC family CW-type zinc finger protein 4 isoform X2

    Conserved Domains (3) summary
    pfam07496
    Location:525 → 569
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:369 → 503
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    cl00075
    Location:142 → 259
    HATPase; Histidine kinase-like ATPase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMD7.2 GenPept UniProtKB/Swiss-Prot:Q8BMD7

Gene LinkOut

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