Idnk idnK gluconokinase homolog (E. coli) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Idnkprovided by MGI
Official Full Name: idnK gluconokinase homolog (E. coli)provided by MGI
Primary source: MGI:MGI:1922981
See related: Ensembl:ENSMUSG00000050002 AllianceGenome:MGI:1922981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5133401N09Rik
Summary: Predicted to enable gluconokinase activity. Predicted to be involved in D-gluconate catabolic process. Predicted to act upstream of or within phosphorylation. Is expressed in nervous system and thymus primordium. Orthologous to human IDNK (IDNK gluconokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 7.5), CNS E11.5 (RPKM 7.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.95 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (58305076..58315358)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (58157649..58164693)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables gluconokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables gluconokinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-gluconate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-gluconate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable gluconokinase

Names: gluconate kinase

NP_001041525.1

EC 2.7.1.12

NP_932121.2

EC 2.7.1.12

XP_036014105.1

EC 2.7.1.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048060.2 → NP_001041525.1 probable gluconokinase isoform b

See identical proteins and their annotated locations for NP_001041525.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.

Source sequence(s)

AC163038, AK032811

Consensus CDS

CCDS36683.1

UniProtKB/TrEMBL

D3Z4J6

Related

ENSMUSP00000105494.3, ENSMUST00000109868.4

Conserved Domains (1) summary

cl17190
Location:6 → 55

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_198004.3 → NP_932121.2 probable gluconokinase isoform a

See identical proteins and their annotated locations for NP_932121.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC163038, AK032811, AK045763, CX206109

Consensus CDS

CCDS36682.1

UniProtKB/Swiss-Prot

Q8R0J8

Related

ENSMUSP00000060218.8, ENSMUST00000051490.15

Conserved Domains (2) summary

COG0703
Location:1 → 184

AroK; Shikimate kinase [Amino acid transport and metabolism]

COG3265
Location:10 → 184

GntK; Gluconate kinase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

58305076..58315358

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158212.1 → XP_036014105.1 probable gluconokinase isoform X1

UniProtKB/TrEMBL

D3Z4J6

Conserved Domains (1) summary

cl17190
Location:6 → 55

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...