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Phf14 PHD finger protein 14 [ Mus musculus (house mouse) ]

Gene ID: 75725, updated on 2-Nov-2024

Summary

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Official Symbol
Phf14provided by MGI
Official Full Name
PHD finger protein 14provided by MGI
Primary source
MGI:MGI:1923539
See related
Ensembl:ENSMUSG00000029629 AllianceGenome:MGI:1923539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0783; 1110001C23Rik; 4932409F11Rik; 5730446A07Rik
Summary
Predicted to enable histone binding activity; histone reader activity; and zinc ion binding activity. Involved in germinal center B cell differentiation. Acts upstream of or within several processes, including lung alveolus development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; hindlimb phalanx; nervous system; and tooth. Orthologous to human PHF14 (PHD finger protein 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 8.4), CNS E14 (RPKM 6.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Phf14 in Genome Data Viewer
Location:
6 A1; 6 5.01 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (11907728..12100155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (11907725..12100156)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene EST AA545190 Neighboring gene STARR-seq mESC enhancer starr_15152 Neighboring gene STARR-seq mESC enhancer starr_15153 Neighboring gene STARR-seq mESC enhancer starr_15154 Neighboring gene STARR-seq mESC enhancer starr_15155 Neighboring gene STARR-seq mESC enhancer starr_15156 Neighboring gene STARR-seq mESC enhancer starr_15157 Neighboring gene STARR-seq mESC enhancer starr_15158 Neighboring gene STARR-seq mESC enhancer starr_15159 Neighboring gene STARR-seq mESC enhancer starr_15161 Neighboring gene STARR-seq mESC enhancer starr_15162 Neighboring gene STARR-seq mESC enhancer starr_15163 Neighboring gene STARR-seq mESC enhancer starr_15164 Neighboring gene STARR-seq mESC enhancer starr_15166 Neighboring gene Ndufa4, mitochondrial complex associated Neighboring gene STARR-seq mESC enhancer starr_15168 Neighboring gene STARR-seq mESC enhancer starr_15169 Neighboring gene STARR-seq mESC enhancer starr_15170 Neighboring gene STARR-seq mESC enhancer starr_15172 Neighboring gene mitochondrial ribosomal protein L32 pseudogene Neighboring gene predicted gene, 32222 Neighboring gene predicted gene, 35961

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PHF14 is required for germinal center B cell development. Zhang L, et al. Cell Immunol, 2020 Dec. PMID 33035772
  2. PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury. Yang B, et al. Sci Rep, 2017 Jan 3. PMID 28045076, Free PMC Article
  3. Depletion of PHF14, a novel histone-binding protein gene, causes neonatal lethality in mice due to respiratory failure. Huang Q, et al. Acta Biochim Biophys Sin (Shanghai), 2013 Aug. PMID 23688586
  4. Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Zhou J, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35074918, Free PMC Article
  5. Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-α. Kitagawa M, et al. J Biol Chem, 2012 Aug 10. PMID 22730381, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PHF14 is required for germinal center B cell development.
    Title: PHF14 is required for germinal center B cell development.
  2. PHF14 expression was upregulated in fibrotic models in vivo and in vitro, and the TGF-beta/smad3/PHF14 pathway acted as a self-limiting mechanism in the TGF-beta-dominated renal pro-fibrotic process by suppressing PDGFR-alpha expression.
    Title: PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury.
  3. results indicated that PHF14 might be an epigenetic regulator and play an important role in the development of multiple organs in mouse
    Title: Depletion of PHF14, a novel histone-binding protein gene, causes neonatal lethality in mice due to respiratory failure.
  4. Phf14 acts as a negative regulator of PDGFRalpha expression in mesenchymal cells undergoing normal and abnormal proliferation, and is a potential target for new treatments of lung fibrosis.
    Title: Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-α.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0783

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in germinal center B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of mesenchymal cell proliferation involved in lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation involved in lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PHD finger protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168382.2 → NP_001161854.1  PHD finger protein 14 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153640, AC153641
    Consensus CDS
    CCDS51720.1
    UniProtKB/Swiss-Prot
    Q810Z6, Q8C284, Q8CGF8, Q9D1Q8, Q9D4H9
    Related
    ENSMUSP00000111173.3, ENSMUST00000115511.9
    Conserved Domains (4) summary
    cd15561
    Location:314 → 370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720 → 769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863 → 911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378 → 491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  2. NM_001362122.1 → NP_001349051.1  PHD finger protein 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153640, AC153641
    Conserved Domains (4) summary
    cd15561
    Location:36 → 92
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442 → 491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:585 → 633
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100 → 213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  3. NM_001362123.1 → NP_001349052.1  PHD finger protein 14 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153640, AC153641
    Conserved Domains (3) summary
    cd15561
    Location:36 → 92
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442 → 491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100 → 213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  4. NM_029404.4 → NP_083680.2  PHD finger protein 14 isoform 2

    See identical proteins and their annotated locations for NP_083680.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 3' exons, but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC153640, AC153641
    Consensus CDS
    CCDS39428.1
    UniProtKB/TrEMBL
    G5E8S0
    Related
    ENSMUSP00000111172.2, ENSMUST00000115510.8
    Conserved Domains (3) summary
    cd15561
    Location:314 → 370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720 → 769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378 → 491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    11907728..12100155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505202.5 → XP_006505265.1  PHD finger protein 14 isoform X7

    See identical proteins and their annotated locations for XP_006505265.1

    Conserved Domains (4) summary
    cd15561
    Location:36 → 92
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442 → 491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:585 → 633
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100 → 213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  2. XM_017321819.3 → XP_017177308.1  PHD finger protein 14 isoform X8

    Conserved Domains (4) summary
    cd15561
    Location:36 → 92
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442 → 491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:585 → 633
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100 → 213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  3. XM_030255656.2 → XP_030111516.1  PHD finger protein 14 isoform X3

    UniProtKB/Swiss-Prot
    Q810Z6, Q8C284, Q8CGF8, Q9D1Q8, Q9D4H9
    Conserved Domains (4) summary
    cd15561
    Location:314 → 370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720 → 769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863 → 911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378 → 491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  4. XM_006505197.5 → XP_006505260.1  PHD finger protein 14 isoform X2

    See identical proteins and their annotated locations for XP_006505260.1

    Conserved Domains (4) summary
    cd15561
    Location:314 → 370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720 → 769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863 → 911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378 → 491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  5. XM_036152388.1 → XP_036008281.1  PHD finger protein 14 isoform X6

    UniProtKB/TrEMBL
    G5E8S0
    Conserved Domains (3) summary
    cd15561
    Location:314 → 370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720 → 769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378 → 491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  6. XM_011241085.4 → XP_011239387.1  PHD finger protein 14 isoform X4

    Conserved Domains (4) summary
    cd15561
    Location:314 → 370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720 → 769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863 → 911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378 → 491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  7. XM_006505196.5 → XP_006505259.1  PHD finger protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006505259.1

    Conserved Domains (4) summary
    cd15561
    Location:314 → 370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720 → 769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:863 → 911
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378 → 491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  8. XM_006505201.5 → XP_006505264.1  PHD finger protein 14 isoform X7

    See identical proteins and their annotated locations for XP_006505264.1

    Conserved Domains (4) summary
    cd15561
    Location:36 → 92
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:442 → 491
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15563
    Location:585 → 633
    PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:100 → 213
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

  9. XM_006505198.5 → XP_006505261.1  PHD finger protein 14 isoform X5

    Conserved Domains (3) summary
    cd15561
    Location:314 → 370
    PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15562
    Location:720 → 769
    PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
    cd15674
    Location:378 → 491
    ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

RNA

  1. XR_004933644.1 RNA Sequence

  2. XR_003956264.2 RNA Sequence

  3. XR_004933636.1 RNA Sequence

  4. XR_004933638.1 RNA Sequence

  5. XR_004933640.1 RNA Sequence

  6. XR_004933637.1 RNA Sequence

  7. XR_004933639.1 RNA Sequence

  8. XR_004933641.1 RNA Sequence

  9. XR_004933643.1 RNA Sequence

  10. XR_004933642.1 RNA Sequence

  11. XR_003956263.2 RNA Sequence

  12. XR_003956260.2 RNA Sequence

  13. XR_004933632.1 RNA Sequence

  14. XR_003956261.2 RNA Sequence

  15. XR_004933634.1 RNA Sequence

  16. XR_004933635.1 RNA Sequence

  17. XR_004933633.1 RNA Sequence

  18. XR_004933631.1 RNA Sequence

  19. XR_377293.5 RNA Sequence

  20. XR_004933645.1 RNA Sequence

  21. XR_001785183.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4H9.2 GenPept UniProtKB/Swiss-Prot:Q9D4H9

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