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ZNF24 zinc finger protein 24 [ Homo sapiens (human) ]

Gene ID: 7572, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF24provided by HGNC
Official Full Name
zinc finger protein 24provided by HGNC
Primary source
HGNC:HGNC:13032
See related
Ensembl:ENSG00000172466 MIM:194534; AllianceGenome:HGNC:13032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX17; RSG-A; ZNF191; ZSCAN3; Zfp191
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 22.0), brain (RPKM 18.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF24 in Genome Data Viewer
Location:
18q12.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (35332227..35344420, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (35523566..35535760, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (32912191..32924384, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 397 Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13222 Neighboring gene zinc finger protein 271, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32904859-32905554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13223 Neighboring gene uncharacterized LOC124904283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9396 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32934967-32935487 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32936140-32936672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9399 Neighboring gene zinc finger protein 396 Neighboring gene ribosomal protein L7a pseudogene 67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells. Jia D, et al. FASEB J, 2015 Apr. PMID 25550468, Free PMC Article
  2. Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24. Li JZ, et al. PLoS One, 2013. PMID 24224020, Free PMC Article
  3. A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor. Li J, et al. BMC Genomics, 2009 May 22. PMID 19463170, Free PMC Article
  4. Overexpression and purification of single zinc finger peptides of human zinc finger protein ZNF191. Zhao DX, et al. Protein Expr Purif, 2007 May. PMID 17270462
  5. ZNF191 alters DNA methylation and activates the PI3K-AKT pathway in hepatoma cells via transcriptional regulation of DNMT1. Liu Y, et al. Cancer Med, 2022 Mar. PMID 35092191, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF191 alters DNA methylation and activates the PI3K-AKT pathway in hepatoma cells via transcriptional regulation of DNMT1.
    Title: ZNF191 alters DNA methylation and activates the PI3K-AKT pathway in hepatoma cells via transcriptional regulation of DNMT1.
  2. Wnt8B, transcriptionally regulated by ZNF191, promotes cell proliferation of hepatocellular carcinoma via Wnt signaling.
    Title: Wnt8B, transcriptionally regulated by ZNF191, promotes cell proliferation of hepatocellular carcinoma via Wnt signaling.
  3. miR-940 promoted gastric cancer progression by directly downregulating ZNF24 expression.
    Title: MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.
  4. In vivo, knockdown of ZNF24 specifically in microvascular endothelial cells led to significantly decreased formation of functional vascular networks.
    Title: The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells.
  5. results suggest that consecutive ZF1-2 is critical for the regulation of ZNF24 nuclear localization and its transactivation function.
    Title: Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24.
  6. ZNF24 represses VEGF transcription through direct binding to an 11-bp fragment of the VEGF proximal promoter and that it functions as a negative regulator of tumor growth by inhibiting angiogenesis.
    Title: Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo.
  7. ZNF24 may be implicated in transcriptional regulation of genes associated with oncogenesis via interaction with H2A.Z.
    Title: A yeast two-hybrid screen identifies histone H2A.Z as a transcription factor ZNF24 interactor.
  8. ZNF191 can directly bind to the CTNNB1 promoter and activate the expression of beta-catenin and its downstream target genes such as cyclin D1 in hepatoma cell lines.
    Title: Zinc finger transcription factor 191, directly binding to β-catenin promoter, promotes cell proliferation of hepatocellular carcinoma.
  9. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription.
    Title: The transcriptional repression of platelet-derived growth factor receptor-beta by the zinc finger transcription factor ZNF24.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in myelination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 24
Names
retinoic acid suppression protein A
zinc finger and SCAN domain-containing protein 3
zinc finger protein 191
zinc finger protein 24 (KOX 17)
zinc finger protein KOX17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308123.2 → NP_001295052.1  zinc finger protein 24 isoform 2

    See identical proteins and their annotated locations for NP_001295052.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' structures compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC116447, AF542097, BG436261, CA314100
    Consensus CDS
    CCDS77175.1
    UniProtKB/Swiss-Prot
    P17028
    Related
    ENSP00000467655.1, ENST00000589881.5
    Conserved Domains (1) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region

  2. NM_001375815.1 → NP_001362744.1  zinc finger protein 24 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116447
    Consensus CDS
    CCDS11912.1
    UniProtKB/Swiss-Prot
    O14754, P17028, Q53YE4, Q6ICR5, Q8IZN4
    Related
    ENSP00000382015.2, ENST00000399061.3
    Conserved Domains (3) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    COG5048
    Location:305 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_006965.4 → NP_008896.2  zinc finger protein 24 isoform 1

    See identical proteins and their annotated locations for NP_008896.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC116447
    Consensus CDS
    CCDS11912.1
    UniProtKB/Swiss-Prot
    O14754, P17028, Q53YE4, Q6ICR5, Q8IZN4
    Related
    ENSP00000261332.5, ENST00000261332.11
    Conserved Domains (3) summary
    smart00431
    Location:48 → 160
    SCAN; leucine rich region
    COG5048
    Location:305 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    35332227..35344420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    35523566..35535760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17028.4 GenPept UniProtKB/Swiss-Prot:P17028

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