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ZNF708 zinc finger protein 708 [ Homo sapiens (human) ]

Gene ID: 7562, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF708provided by HGNC
Official Full Name
zinc finger protein 708provided by HGNC
Primary source
HGNC:HGNC:12945
See related
Ensembl:ENSG00000182141 AllianceGenome:HGNC:12945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX8; ZNF15; ZNF15L1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 4.2), ovary (RPKM 3.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF708 in Genome Data Viewer
Location:
19p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21291160..21329410, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21429845..21468128, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21473962..21512212, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36a pseudogene 51 Neighboring gene MPRA-validated peak3409 silencer Neighboring gene COX16 pseudogene 1 Neighboring gene vomeronasal 1 receptor 83 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr19:21500539-21501043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21510155-21510676 Neighboring gene BCL2 interacting protein 3 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14383 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21512069-21513057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21540515-21541072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14385 Neighboring gene zinc finger protein 738 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:21579974-21580212 Neighboring gene zinc finger protein 493

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Conserved KRAB protein domain identified upstream from the zinc finger region of Kox 8. Thiesen HJ, et al. Nucleic Acids Res, 1991 Jul 25. PMID 1861988, Free PMC Article
  2. Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22. Rousseau-Merck MF, et al. Ann Genet, 1995. PMID 7486829
  3. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article
  4. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
  5. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16755, FLJ46310, DKFZp686L10267

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 708
Names
ZNF15, ZNF15L1
zinc finger protein 15-like 1 (KOX 8)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297560.2 → NP_001284489.1  zinc finger protein 708 isoform 2

    See identical proteins and their annotated locations for NP_001284489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC022432, AK311130, BX103920, BX647526, CD704852, DB216212
    UniProtKB/Swiss-Prot
    P17019
    Conserved Domains (3) summary
    COG5048
    Location:78 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:190 → 210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:258 → 282
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001297561.2 → NP_001284490.1  zinc finger protein 708 isoform 2

    See identical proteins and their annotated locations for NP_001284490.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC022432, AK311130, BX103920, BX647526, CD704852
    UniProtKB/Swiss-Prot
    P17019
    Conserved Domains (3) summary
    COG5048
    Location:78 → 488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:190 → 210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:258 → 282
    zf-H2C2_2; Zinc-finger double domain

  3. NM_021269.3 → NP_067092.2  zinc finger protein 708 isoform 1

    See identical proteins and their annotated locations for NP_067092.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC022432
    Consensus CDS
    CCDS32980.1
    UniProtKB/Swiss-Prot
    P17019, Q6ZMR0
    Related
    ENSP00000349401.2, ENST00000356929.3
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:142 → 552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254 → 274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:322 → 346
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    21291160..21329410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027203.3 → XP_016882692.1  zinc finger protein 708 isoform X2

  2. XM_047439310.1 → XP_047295266.1  zinc finger protein 708 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    21429845..21468128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321946.1 → XP_054177921.1  zinc finger protein 708 isoform X2

  2. XM_054321945.1 → XP_054177920.1  zinc finger protein 708 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17019.6 GenPept UniProtKB/Swiss-Prot:P17019

Gene LinkOut

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