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ZNF12 zinc finger protein 12 [ Homo sapiens (human) ]

Gene ID: 7559, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF12provided by HGNC
Official Full Name
zinc finger protein 12provided by HGNC
Primary source
HGNC:HGNC:12902
See related
Ensembl:ENSG00000164631 MIM:194536; AllianceGenome:HGNC:12902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX3; HZF11; GIOT-3; ZNF325
Summary
This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.8), endometrium (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6688433..6706947, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6807510..6826041, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6728064..6746578, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:6703791-6704291 Neighboring gene uncharacterized LOC124901583 Neighboring gene zinc finger protein 33B pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:6746247-6746746 Neighboring gene speedy/RINGO cell cycle regulator family member E20, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25633 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6768255-6769230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17959 Neighboring gene PMS2 C-terminal like (pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Lagou V, et al. Nat Commun, 2021 Jan 5. PMID 33402679, Free PMC Article
  2. ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity. Zhao Y, et al. Biochem Biophys Res Commun, 2006 Aug 11. PMID 16806083
  3. Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively. Seite P, et al. Hum Genet, 1991 Apr. PMID 2026422
  4. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
    Title: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
  2. A zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity
    Title: ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 12 (ZNF12) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 12
Names
gonadotropin inducible transcription repressor 3
gonadotropin-inducible ovary transcription repressor 3
zinc finger protein 11
zinc finger protein 325
zinc finger protein KOX3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006956.3 → NP_008887.2  zinc finger protein 12 isoform b

    See identical proteins and their annotated locations for NP_008887.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC073343, AI879099, BC051892, BX114779
    Consensus CDS
    CCDS47539.1
    UniProtKB/Swiss-Prot
    P17014
    Related
    ENSP00000344745.5, ENST00000342651.9
    Conserved Domains (6) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 645
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289 → 309
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:539 → 561
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:441 → 466
    zf-H2C2_2; Zinc-finger double domain

  2. NM_016265.4 → NP_057349.2  zinc finger protein 12 isoform a

    See identical proteins and their annotated locations for NP_057349.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC073343, AF505656, AI879099, BC051892, BX114779
    Consensus CDS
    CCDS47538.1
    UniProtKB/Swiss-Prot
    A8MYC4, A8WFQ8, B2RNQ7, B4DF45, P17014, Q6N016, Q8NHZ0, Q9H9P0, Q9ULZ6
    Related
    ENSP00000385939.1, ENST00000405858.6
    Conserved Domains (6) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:307 → 683
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327 → 347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:577 → 599
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:479 → 504
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6688433..6706947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6807510..6826041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17014.3 GenPept UniProtKB/Swiss-Prot:P17014

Gene LinkOut

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