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Sgf29 SAGA complex associated factor 29 [ Mus musculus (house mouse) ]

Gene ID: 75565, updated on 2-Nov-2024

Summary

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Official Symbol
Sgf29provided by MGI
Official Full Name
SAGA complex associated factor 29provided by MGI
Primary source
MGI:MGI:1922815
See related
Ensembl:ENSMUSG00000030714 AllianceGenome:MGI:1922815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc101; 1700023O11Rik; 9530025I05Rik
Summary
Enables methylation-dependent protein binding activity. Involved in several processes, including regulation of DNA repair; regulation of cell division; and regulation of embryonic development. Part of ATAC complex. Is expressed in genital tubercle; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human SGF29 (SAGA complex associated factor 29). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 127.2), colon adult (RPKM 18.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Sgf29 in Genome Data Viewer
Location:
7 F3; 7 69.23 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126247558..126271951)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126648386..126672779)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39086 Neighboring gene predicted gene, 39087 Neighboring gene nuclear protein transcription regulator 1 Neighboring gene STARR-seq mESC enhancer starr_20153 Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6601 Neighboring gene STARR-positive B cell enhancer ABC_E3751 Neighboring gene STARR-positive B cell enhancer ABC_E2252 Neighboring gene sulfotransferase family 1A, phenol-preferring, member 1 pseudogene Neighboring gene SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Long L, et al. Nature, 2021 Dec. PMID 34795452, Free PMC Article
  2. RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair. Xiao Y, et al. Bone Res, 2022 Feb 24. PMID 35210392, Free PMC Article
  3. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
  4. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Nagy Z, et al. Cell Mol Life Sci, 2010 Feb. PMID 19936620, Free PMC Article
  5. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methylation-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
part_of ATAC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SAGA-type complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA-type complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SAGA-associated factor 29
Names
SAGA-associated factor 29 homolog
coiled-coil domain containing 101
coiled-coil domain-containing protein 101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029339.3 → NP_083615.3  SAGA-associated factor 29

    See identical proteins and their annotated locations for NP_083615.3

    Status: VALIDATED

    Source sequence(s)
    AK006287, AK139102, BE685896
    Consensus CDS
    CCDS21837.1
    UniProtKB/Swiss-Prot
    Q8R0I6, Q9DA08
    Related
    ENSMUSP00000032956.9, ENSMUST00000032956.10
    Conserved Domains (1) summary
    pfam07039
    Location:158 → 288
    DUF1325; SGF29 tudor-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126247558..126271951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312365.2 → XP_017167854.1  SAGA-associated factor 29 isoform X1

    UniProtKB/Swiss-Prot
    Q8R0I6, Q9DA08
    Conserved Domains (1) summary
    pfam07039
    Location:158 → 288
    DUF1325; SGF29 tudor-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DA08.1 GenPept UniProtKB/Swiss-Prot:Q9DA08

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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