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Fabp12 fatty acid binding protein 12 [ Mus musculus (house mouse) ]

Gene ID: 75497, updated on 2-Nov-2024

Summary

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Official Symbol
Fabp12provided by MGI
Official Full Name
fatty acid binding protein 12provided by MGI
Primary source
MGI:MGI:1922747
See related
Ensembl:ENSMUSG00000027530 AllianceGenome:MGI:1922747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700008G05Rik
Summary
Predicted to enable fatty acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be active in cytosol and nucleus. Is expressed in retina inner nuclear layer and retina outer nuclear layer. Orthologous to human FABP12 (fatty acid binding protein 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 2.8), liver E18 (RPKM 0.8) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Fabp12 in Genome Data Viewer
Location:
3 A1; 3 2.57 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10309269..10366575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10244209..10301515, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 9, testis Neighboring gene fatty acid binding protein 4, adipocyte Neighboring gene STARR-seq mESC enhancer starr_06936 Neighboring gene STARR-positive B cell enhancer ABC_E10175 Neighboring gene STARR-seq mESC enhancer starr_06939 Neighboring gene predicted gene, 37316 Neighboring gene inositol (myo)-1(or 4)-monophosphatase 1 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cell-type-specific regulation of genes involved in testicular lipid metabolism: fatty acid-binding proteins, diacylglycerol acyltransferases, and perilipin 2. Oresti GM, et al. Reproduction, 2013. PMID 23962454
  2. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. Liu RZ, et al. Genomics, 2008 Dec. PMID 18786628
  3. Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Sah RK, et al. Int J Mol Sci, 2020 Nov 3. PMID 33153107, Free PMC Article
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FABP12 arose as the result of tandem gene duplication, a mechanism that may have been instrumental to the expansion of the FABP family.
    Title: A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fatty acid-binding protein 12
Names
intracellular fatty acid-binding protein FABP12
probable fatty acid-binding protein ENSP00000353650 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357159.1 → NP_001344088.1  fatty acid-binding protein 12

    Status: VALIDATED

    Source sequence(s)
    AC123726, BC030910
    Consensus CDS
    CCDS17239.1
    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Related
    ENSMUSP00000112958.2, ENSMUST00000119761.2
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

  2. NM_001357160.1 → NP_001344089.1  fatty acid-binding protein 12

    Status: VALIDATED

    Source sequence(s)
    AC123726, AK005765, BC030910
    Consensus CDS
    CCDS17239.1
    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Related
    ENSMUSP00000112464.2, ENSMUST00000117917.8
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

  3. NM_001357161.1 → NP_001344090.1  fatty acid-binding protein 12

    Status: VALIDATED

    Source sequence(s)
    AC123726, AK005765, BC030910
    Consensus CDS
    CCDS17239.1
    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Related
    ENSMUSP00000131101.2, ENSMUST00000172126.8
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

  4. NM_029310.1 → NP_083586.1  fatty acid-binding protein 12

    See identical proteins and their annotated locations for NP_083586.1

    Status: VALIDATED

    Source sequence(s)
    BC030910
    Consensus CDS
    CCDS17239.1
    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Related
    ENSMUSP00000029043.7, ENSMUST00000029043.13
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    10309269..10366575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319783.2 → XP_017175272.1  fatty acid-binding protein 12 isoform X1

    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

  2. XM_006530099.5 → XP_006530162.1  fatty acid-binding protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006530162.1

    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

  3. XM_036163370.1 → XP_036019263.1  fatty acid-binding protein 12 isoform X1

    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

  4. XM_036163371.1 → XP_036019264.1  fatty acid-binding protein 12 isoform X1

    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

  5. XM_006530096.4 → XP_006530159.1  fatty acid-binding protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006530159.1

    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

  6. XM_006530097.3 → XP_006530160.1  fatty acid-binding protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006530160.1

    UniProtKB/Swiss-Prot
    B7SUM9, Q9DAK4
    Conserved Domains (1) summary
    cd19617
    Location:4 → 131
    FABP12; fatty acid-binding protein 12

RNA

  1. XR_004941410.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAK4.1 GenPept UniProtKB/Swiss-Prot:Q9DAK4

Gene LinkOut

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