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Spata19 spermatogenesis associated 19 [ Mus musculus (house mouse) ]

Gene ID: 75469, updated on 2-Nov-2024

Summary

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Official Symbol
Spata19provided by MGI
Official Full Name
spermatogenesis associated 19provided by MGI
Primary source
MGI:MGI:1922719
See related
Ensembl:ENSMUSG00000031991 AllianceGenome:MGI:1922719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
spergen-1; 1700001L23Rik
Summary
Involved in sperm mitochondrion organization. Located in mitochondrial outer membrane and sperm midpiece. Orthologous to human SPATA19 (spermatogenesis associated 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 181.3) See more
Orthologs
human all
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Genomic context

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See Spata19 in Genome Data Viewer
Location:
9 A4; 9 12.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (27308103..27313007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (27396807..27401711)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53501 Neighboring gene STARR-positive B cell enhancer mm9_chr9:27020677-27020977 Neighboring gene STARR-seq mESC enhancer starr_23621 Neighboring gene immunoglobulin superfamily, member 9B Neighboring gene STARR-seq mESC enhancer starr_23623 Neighboring gene predicted gene, 30791 Neighboring gene STARR-seq mESC enhancer starr_23625 Neighboring gene STARR-seq mESC enhancer starr_23626 Neighboring gene ADP-ribosylation factor-like 4A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Spata-19 new variant with expression beyond meiotic phase of mouse testis development. Nourashrafeddin S, et al. Rep Biochem Mol Biol, 2014 Apr. PMID 26989727, Free PMC Article
  2. Spata19 is critical for sperm mitochondrial function and male fertility. Mi Y, et al. Mol Reprod Dev, 2015 Nov. PMID 26265198
  3. Cloning and characterization of a mouse spergen-1 localized in sperm mitochondria. Matsuoka Y, et al. Int J Androl, 2004 Jun. PMID 15139970
  4. Isolation and expression analysis of the human testis-specific gene, SPERGEN-1, a spermatogenic cell-specific gene-1. Miyamoto T, et al. J Assist Reprod Genet, 2003 Feb. PMID 12688595, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
spermatogenesis-associated protein 19, mitochondrial
Names
spermatogenic cell-specific gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305058.1 → NP_001291987.1  spermatogenesis-associated protein 19, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001291987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate 5' exons, uses an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC154374, AK005610
    Consensus CDS
    CCDS90524.1
    UniProtKB/TrEMBL
    A0A1L1SQQ1
    Related
    ENSMUSP00000149525.2, ENSMUST00000214287.2
    Conserved Domains (1) summary
    pfam15212
    Location:11 → 119
    SPATA19; Spermatogenesis-associated protein 19, mitochondrial

  2. NM_029299.3 → NP_083575.1  spermatogenesis-associated protein 19, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_083575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154374, AK005610
    Consensus CDS
    CCDS22941.1
    UniProtKB/Swiss-Prot
    Q810M9, Q9DAQ9
    UniProtKB/TrEMBL
    I6ZYN5
    Related
    ENSMUSP00000034473.6, ENSMUST00000034473.7
    Conserved Domains (1) summary
    pfam15212
    Location:25 → 154
    SPATA19; Spermatogenesis-associated protein 19, mitochondrial

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    27308103..27313007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAQ9.1 GenPept UniProtKB/Swiss-Prot:Q9DAQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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