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Anapc15 anaphase promoting complex C subunit 15 [ Mus musculus (house mouse) ]

Gene ID: 75430, updated on 28-Oct-2024

Summary

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Official Symbol
Anapc15provided by MGI
Official Full Name
anaphase promoting complex C subunit 15provided by MGI
Primary source
MGI:MGI:1922680
See related
Ensembl:ENSMUSG00000030649 AllianceGenome:MGI:1922680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APC15; 3200002M19Rik; 6330414C15Rik
Summary
Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to be part of anaphase-promoting complex. Is expressed in several structures, including adrenal gland; brain; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ANAPC15 (anaphase promoting complex subunit 15). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.4), CNS E14 (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Anapc15 in Genome Data Viewer
Location:
7 E2; 7 54.68 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101530508..101551056)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101881300..101901849)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene folate receptor alpha Neighboring gene STARR-seq mESC enhancer starr_19700 Neighboring gene predicted gene, 35597 Neighboring gene STARR-positive B cell enhancer ABC_E2837 Neighboring gene STARR-positive B cell enhancer ABC_E1350 Neighboring gene STARR-positive B cell enhancer ABC_E1089 Neighboring gene transmembrane O-methyltransferase Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene leucine rich repeat containing 51 Neighboring gene STARR-positive B cell enhancer ABC_E554

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide screening reveals the genetic basis of mammalian embryonic eye development. Chee JM, et al. BMC Biol, 2023 Feb 3. PMID 36737727, Free PMC Article
  2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein branched polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
part_of anaphase-promoting complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 15
Names
anaphase prompoting complex C subunit 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291348.1 → NP_001278277.1  anaphase-promoting complex subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001278277.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK135201, AK139635, CF166358
    Consensus CDS
    CCDS80760.1
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Conserved Domains (1) summary
    pfam15243
    Location:22 → 82
    ANAPC15; Anaphase-promoting complex subunit 15

  2. NM_001291349.1 → NP_001278278.1  anaphase-promoting complex subunit 15 isoform b

    See identical proteins and their annotated locations for NP_001278278.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK135201, BB636259, CF166358
    Consensus CDS
    CCDS80762.1
    UniProtKB/TrEMBL
    A0A1W2P6Q9, H3BIU1
    Related
    ENSMUSP00000102586.2, ENSMUST00000106973.8
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  3. NM_001291352.1 → NP_001278281.1  anaphase-promoting complex subunit 15 isoform c

    See identical proteins and their annotated locations for NP_001278281.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice junction at the 3' end of one exon and at the 5' end of the next exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
    Source sequence(s)
    AK135201, DV659149
    Consensus CDS
    CCDS21518.1
    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Related
    ENSMUSP00000147669.2, ENSMUST00000210984.2
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  4. NM_001291353.1 → NP_001278282.1  anaphase-promoting complex subunit 15 isoform c

    See identical proteins and their annotated locations for NP_001278282.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice junction at the 3' end of one exon and at the 5' end of the next exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
    Source sequence(s)
    AC167240, AK135201
    Consensus CDS
    CCDS21518.1
    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Related
    ENSMUSP00000102591.2, ENSMUST00000106978.8
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  5. NM_027532.4 → NP_081808.2  anaphase-promoting complex subunit 15 isoform c

    See identical proteins and their annotated locations for NP_081808.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of one exon and at the 5' end of the next exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (c).
    Source sequence(s)
    AK135201, CF166358
    Consensus CDS
    CCDS21518.1
    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Related
    ENSMUSP00000114771.2, ENSMUST00000144207.9
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101530508..101551056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241930.2 → XP_011240232.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_011240232.1

    UniProtKB/TrEMBL
    G5E8M3
    Related
    ENSMUSP00000095839.3, ENSMUST00000098237.9
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  2. XM_036153505.1 → XP_036009398.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/TrEMBL
    G5E8M3
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  3. XM_011241935.4 → XP_011240237.1  anaphase-promoting complex subunit 15 isoform X4

    See identical proteins and their annotated locations for XP_011240237.1

    UniProtKB/TrEMBL
    A0A1W2P6Q9, H3BIU1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  4. XM_006508282.5 → XP_006508345.1  anaphase-promoting complex subunit 15 isoform X2

    See identical proteins and their annotated locations for XP_006508345.1

    UniProtKB/TrEMBL
    Q9D3A0
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  5. XM_006508285.5 → XP_006508348.1  anaphase-promoting complex subunit 15 isoform X2

    See identical proteins and their annotated locations for XP_006508348.1

    UniProtKB/TrEMBL
    Q9D3A0
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  6. XM_036153506.1 → XP_036009399.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    Q9D3A0
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  7. XM_006508280.5 → XP_006508343.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_006508343.1

    UniProtKB/TrEMBL
    G5E8M3
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  8. XM_036153514.1 → XP_036009407.1  anaphase-promoting complex subunit 15 isoform X4

    UniProtKB/TrEMBL
    A0A1W2P6Q9, H3BIU1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  9. XM_036153507.1 → XP_036009400.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    Q9D3A0
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  10. XM_006508284.5 → XP_006508347.1  anaphase-promoting complex subunit 15 isoform X2

    See identical proteins and their annotated locations for XP_006508347.1

    UniProtKB/TrEMBL
    Q9D3A0
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  11. XM_011241931.4 → XP_011240233.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_011240233.1

    UniProtKB/TrEMBL
    G5E8M3
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  12. XM_036153513.1 → XP_036009406.1  anaphase-promoting complex subunit 15 isoform X4

    UniProtKB/TrEMBL
    A0A1W2P6Q9, H3BIU1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  13. XM_030243050.2 → XP_030098910.1  anaphase-promoting complex subunit 15 isoform X3

    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  14. XM_036153512.1 → XP_036009405.1  anaphase-promoting complex subunit 15 isoform X4

    UniProtKB/TrEMBL
    A0A1W2P6Q9, H3BIU1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  15. XM_036153510.1 → XP_036009403.1  anaphase-promoting complex subunit 15 isoform X3

    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  16. XM_030243051.2 → XP_030098911.1  anaphase-promoting complex subunit 15 isoform X3

    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  17. XM_017312358.3 → XP_017167847.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    Q9D3A0
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  18. XM_030243052.2 → XP_030098912.1  anaphase-promoting complex subunit 15 isoform X3

    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Related
    ENSMUSP00000136164.2, ENSMUST00000178851.2
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  19. XM_011241932.2 → XP_011240234.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_011240234.1

    UniProtKB/TrEMBL
    G5E8M3
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  20. XM_006508279.3 → XP_006508342.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_006508342.1

    UniProtKB/TrEMBL
    G5E8M3
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  21. XM_011241933.2 → XP_011240235.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_011240235.1

    UniProtKB/TrEMBL
    G5E8M3
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  22. XM_030243049.2 → XP_030098909.1  anaphase-promoting complex subunit 15 isoform X3

    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  23. XM_030243054.1 → XP_030098914.1  anaphase-promoting complex subunit 15 isoform X4

    UniProtKB/TrEMBL
    A0A1W2P6Q9, H3BIU1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  24. XM_036153511.1 → XP_036009404.1  anaphase-promoting complex subunit 15 isoform X4

    UniProtKB/TrEMBL
    A0A1W2P6Q9, H3BIU1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  25. XM_036153509.1 → XP_036009402.1  anaphase-promoting complex subunit 15 isoform X3

    UniProtKB/Swiss-Prot
    P60007, Q3UT90, Q3UXV5
    UniProtKB/TrEMBL
    A0A1W2P6Q9
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  26. XM_036153508.1 → XP_036009401.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    Q9D3A0
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60007.1 GenPept UniProtKB/Swiss-Prot:P60007

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