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Sv2c synaptic vesicle glycoprotein 2c [ Mus musculus (house mouse) ]

Gene ID: 75209, updated on 2-Nov-2024

Summary

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Official Symbol
Sv2cprovided by MGI
Official Full Name
synaptic vesicle glycoprotein 2cprovided by MGI
Primary source
MGI:MGI:1922459
See related
Ensembl:ENSMUSG00000051111 AllianceGenome:MGI:1922459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930527L09Rik
Summary
Predicted to enable transmembrane transporter activity. Involved in regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in dopaminergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SV2C (synaptic vesicle glycoprotein 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 6.9), frontal lobe adult (RPKM 2.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Sv2c in Genome Data Viewer
Location:
13 D1; 13 50.47 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (96091102..96270837, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95959443..96132577, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene predicted gene, 32702 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662105-96662214 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662521-96662711 Neighboring gene predicted gene, 24032 Neighboring gene STARR-positive B cell enhancer mm9_chr13:96730579-96730880 Neighboring gene STARR-seq mESC enhancer starr_35333 Neighboring gene predicted gene, 57605 Neighboring gene STARR-seq mESC enhancer starr_35337 Neighboring gene basic transcription factor 3 like 4B Neighboring gene predicted gene 17190 Neighboring gene predicted gene, 23955 Neighboring gene predicted gene 29543 Neighboring gene STARR-seq mESC enhancer starr_35340 Neighboring gene STARR-seq mESC enhancer starr_35341 Neighboring gene STARR-seq mESC enhancer starr_35342 Neighboring gene STARR-seq mESC enhancer starr_35344 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:97157941-97158317 Neighboring gene SNF8, ESCRT-II complex subunit, homolog pseudogene Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene POC5 centriolar protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain. Dunn AR, et al. Brain Res, 2019 Jan 1. PMID 29274878, Free PMC Article
  2. A role for Sv2c in basal ganglia functions. Dardou D, et al. Brain Res, 2013 Apr 24. PMID 23458503
  3. Distribution of SV2C mRNA and protein expression in the mouse brain with a particular emphasis on the basal ganglia system. Dardou D, et al. Brain Res, 2011 Jan 7. PMID 20869353
  4. Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. Bucher ML, et al. Eur J Neurosci, 2024 May. PMID 38532289
  5. Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C. Peng C, et al. Neurosci Bull, 2018 Oct. PMID 29713895, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity.
    Title: Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity.
  2. Study showed that SV2C is highly expressed in the basal ganglia and hippocampus of mice and that there is a specific and progressive decrease in SV2C mRNA and protein expression in both Huntington's disease (HD) mice and a cell model. These findings suggest that the synaptic dysfunction in HD results from the mutant Htt-mediated inhibition of SV2C transcriptional expression.
    Title: Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C.
  3. Results showed that SV2C, a poorly functionally characterized protein is strongly involved in normal operation of the basal ganglia network and could be also involved in system adaptation in basal ganglia pathological conditions.
    Title: A role for Sv2c in basal ganglia functions.
  4. SV2C protein was expressed in a small subset of brain regions including the olfactory bulb, olfactory tubercle, nucleus accumbens, caudate-putamen, ventral pallidum, globus pallidus, substantia nigra and the ventral tegmental area.
    Title: Distribution of SV2C mRNA and protein expression in the mouse brain with a particular emphasis on the basal ganglia system.
  5. findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A
    Title: SV2 is the protein receptor for botulinum neurotoxin A.
  6. Botulinum neurotoxin A also interacts with a synaptic vesicle protein, the synaptic vesicle glycoprotein 2C (SV2C), but not with the homologous proteins SV2A and SV2B.
    Title: The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dopaminergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptic vesicle glycoprotein 2C
Names
synaptic vesicle protein 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029210.1 → NP_083486.1  synaptic vesicle glycoprotein 2C

    See identical proteins and their annotated locations for NP_083486.1

    Status: VALIDATED

    Source sequence(s)
    AC129327, AC153134
    Consensus CDS
    CCDS49333.1
    UniProtKB/Swiss-Prot
    Q69ZS6
    UniProtKB/TrEMBL
    A2RSH4
    Related
    ENSMUSP00000124473.2, ENSMUST00000161263.8
    Conserved Domains (1) summary
    TIGR01299
    Location:1 → 727
    synapt_SV2; synaptic vesicle protein SV2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    96091102..96270837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158202.1 → XP_036014095.1  synaptic vesicle glycoprotein 2C isoform X1

    UniProtKB/Swiss-Prot
    Q69ZS6
    UniProtKB/TrEMBL
    A2RSH4
    Conserved Domains (1) summary
    TIGR01299
    Location:1 → 727
    synapt_SV2; synaptic vesicle protein SV2

  2. XM_030247440.2 → XP_030103300.1  synaptic vesicle glycoprotein 2C isoform X2

    Conserved Domains (1) summary
    TIGR01299
    Location:22 → 307
    synapt_SV2; synaptic vesicle protein SV2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZS6.2 GenPept UniProtKB/Swiss-Prot:Q69ZS6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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