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fam168a family with sequence similarity 168 member A [ Danio rerio (zebrafish) ]

Gene ID: 751761, updated on 2-Nov-2024

Summary

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Official Symbol
fam168aprovided by ZNC
Official Full Name
family with sequence similarity 168 member Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060825-128
See related
Ensembl:ENSDARG00000098832 AllianceGenome:ZFIN:ZDB-GENE-060825-128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153007
Summary
Predicted to be involved in positive regulation of base-excision repair. Is expressed in brain. Orthologous to human FAM168A (family with sequence similarity 168 member A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See fam168a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (2837563..2935707)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (6551956..6650253)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene RELT TNF receptor Neighboring gene Rho guanine nucleotide exchange factor (GEF) 17 Neighboring gene rho guanine nucleotide exchange factor 17 Neighboring gene pyrimidinergic receptor P2Y6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation. Zhang T, et al. Biochim Biophys Acta Gene Regul Mech, 2020 Oct. PMID 32745624
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC153007

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein FAM168A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045470.2 → NP_001038935.2  protein FAM168A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    EH438334, EH582125, EH601884
    UniProtKB/TrEMBL
    A0A0H2UKU6, A0A8M1NAQ8
    Related
    ENSDARP00000139676.1, ENSDART00000160228.2
    Conserved Domains (1) summary
    pfam14944
    Location:32 → 224
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  2. NM_001244879.1 → NP_001231808.1  protein FAM168A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    EH438334, EH582125, EH601884
    UniProtKB/TrEMBL
    A0A0H2UKW4, A0A8M1P263
    Related
    ENSDARP00000140889.1, ENSDART00000171495.2
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 235
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    2837563..2935707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173612.5 → XP_005173669.1  protein FAM168A isoform X1

    UniProtKB/TrEMBL
    A0A8M2BKV9
    Conserved Domains (1) summary
    pfam14944
    Location:32 → 266
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  2. XM_005173614.5 → XP_005173671.1  protein FAM168A isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKV3
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 193
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
Nucleotide Protein Strain
Heading Accession and Version

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