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KRAS KRAS proto-oncogene, GTPase [ Felis catus (domestic cat) ]

Gene ID: 751104, updated on 17-Aug-2024

Summary

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Official Symbol
KRAS
Official Full Name
KRAS proto-oncogene, GTPase
Primary source
VGNC:VGNC:84048
See related
EnsemblRapid:ENSFCTG00005013354
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as
K-RAS
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: B4
Exon count:
7
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (58557550..58597919, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (60631473..60670232, complement)

Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene uncharacterized LOC111561336 Neighboring gene uncharacterized LOC123386555

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma. Crozier C, et al. J Comp Pathol, 2016 Jul. PMID 27290644
  2. High sequence similarity within ras exons 1 and 2 in different mammalian species and phylogenetic divergence of the ras gene family. Watzinger F, et al. Mamm Genome, 1998 Mar. PMID 9501305
  3. Sequencing and comparative genomic analysis of 1227 Felis catus cDNA sequences enriched for developmental, clinical and nutritional phenotypes. Irizarry KJ, et al. BMC Genomics, 2012 Jan 18. PMID 22257742, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KRAS mutations do not play a critical role in feline or canine pancreatic acinar cell carcinomas
    Title: KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GDP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
GTPase KRas
Names
ras p21

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    58557550..58597919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023256853.2 → XP_023112621.1  GTPase KRas isoform X2

    Related
    ENSFCTP00005026495.1, ENSFCTT00005037943.1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. XM_045061560.1 → XP_044917495.1  GTPase KRas isoform X3

    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  3. XM_045061559.1 → XP_044917494.1  GTPase KRas isoform X1

    UniProtKB/TrEMBL
    A0A2I2UHH3
    Related
    ENSFCTP00005026576.1, ENSFCTT00005038045.1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
Nucleotide Protein
Heading Accession and Version

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