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Tmem65 transmembrane protein 65 [ Mus musculus (house mouse) ]

Gene ID: 74868, updated on 28-Oct-2024

Summary

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Official Symbol
Tmem65provided by MGI
Official Full Name
transmembrane protein 65provided by MGI
Primary source
MGI:MGI:1922118
See related
Ensembl:ENSMUSG00000062373 AllianceGenome:MGI:1922118
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610029O13Rik; 4930438D12Rik
Summary
Involved in cardiac conduction; cardiac ventricle development; and regulation of cardiac conduction. Located in intercalated disc and plasma membrane. Is expressed in dentate gyrus subgranular zone. Orthologous to human TMEM65 (transmembrane protein 65). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in heart adult (RPKM 30.6), cerebellum adult (RPKM 15.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem65 in Genome Data Viewer
Location:
15 D1; 15 25.09 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58654118..58695510, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58782269..58823663, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene fer-1 like family member 6 Neighboring gene STARR-seq mESC enhancer starr_38758 Neighboring gene predicted gene, 36451 Neighboring gene STARR-seq mESC enhancer starr_38759 Neighboring gene predicted gene, 41329 Neighboring gene STARR-positive B cell enhancer ABC_E5480 Neighboring gene predicted gene, 24041 Neighboring gene STARR-positive B cell enhancer ABC_E3141 Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene tRNA methyltransferase 12 Neighboring gene predicted gene, 36509

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts. Teng ACT, et al. Nat Commun, 2022 Oct 18. PMID 36257954, Free PMC Article
  2. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Sharma P, et al. Nat Commun, 2015 Sep 25. PMID 26403541
  3. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
  4. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
    Title: Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
  2. Tmem65 is an intercalated disc protein that interacts with and functionally regulates ventricular Cx43.
    Title: Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac conduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cardiac ventricle development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cardiac conduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in intercalated disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175212.4 → NP_780421.2  transmembrane protein 65

    See identical proteins and their annotated locations for NP_780421.2

    Status: PROVISIONAL

    Source sequence(s)
    AC107772
    Consensus CDS
    CCDS27493.1
    UniProtKB/Swiss-Prot
    Q4VAE3, Q810S8
    Related
    ENSMUSP00000071984.6, ENSMUST00000072113.6
    Conserved Domains (1) summary
    pfam10507
    Location:114 → 221
    DUF2453; Protein of unknown function (DUF2453)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    58654118..58695510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521504.5 → XP_006521567.1  transmembrane protein 65 isoform X1

    Conserved Domains (1) summary
    pfam10507
    Location:141 → 248
    TMEM65; Transmembrane protein 65

  2. XM_036159621.1 → XP_036015514.1  transmembrane protein 65 isoform X2

    Conserved Domains (1) summary
    pfam10507
    Location:36 → 143
    TMEM65; Transmembrane protein 65

  3. XM_011245759.4 → XP_011244061.1  transmembrane protein 65 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VAE3.1 GenPept UniProtKB/Swiss-Prot:Q4VAE3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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